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Diss Factsheets
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EC number: 203-319-5 | CAS number: 105-65-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- Diisopropyl Xanthogen Disulphide
- Type of composition:
- legal entity composition of the substance
- State / form:
- solid: particulate/powder
- >= 97.8 - <= 100 % (w/w)
- Reference substance:
- Diisopropyl Xanthogen Disulphide
- Reference substance:
- Diisopropyl Xanthogen Disulphide
- This impurity is considered relevant for the classification and labelling of the substance
- PBT status:
- the substance is not PBT / vPvB
- Justification:
DIXD is a known to be a hydrolytic breakdown product from AS100 (the tetrasulfide, longer chain xanthogen) in water in pH above 7 (basic conditions). Review of aquatic toxicity results from AS100 is a valid method of read-across and AS100, pre-2000, had significant quantities of DIXD within its composition (up to 8%w/w). Results from the AS100 studies showed that it does degrade to DIXD and there is a question as to whether DIXD is persistent. A recent Chinese Fish Toxicity study has been used as the main study to denote low/non toxic behaviour for DIXD. This removes the possibility of DIXD being a PBT.
A recent assessment of AS100/DIXD by BIBRA has highlighted relevant studies demonstrating a common metabolic pathway for diallyl duslphides to be oxidised to thiosulphinate, by Cytochrome P450 enzymes and into allyl mercaptans. This is further metabolised by conujugation with glutathione (Teyssier and Siess, 2000) and subsequent metabolism resulting in a common product - methylethyl thioformate. This is strong evidence that there would be no bioaccumulation of DIXD which is also corroborated with the BCF predicted value of 33.6 - from OECD Canadian Domestic Substance List - https://canadachemicals.oecd.org/ChemicalDetails.aspx?ChemicalID=EB41B8A8-0D5C-46A2-A5DE-12F6C121BB02. This also negates the possible designation of DIXD as being a vPvB.
- Likely routes of exposure:
Human exposure:
Oral - not by dermal or inhalation
Environmental exposure:
Water
Pattern of exposure:
Accidental
Reference
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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