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Diss Factsheets
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EC number: 611-431-4 | CAS number: 569316-81-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental start date 21 April 2017 Experimental completion date 05 May 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on test solutions:
- Analysis of the freshly prepared bulk test preparations at 0 and 72 hours showed measured test concentrations to be 90 and 88mg/L. There was no significant change in the measured concentrations of the old or expired test media at 24 and 96 hours and so the results are based on nominal concentration.
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- The test was carried out using juvenile rainbow trout. The stock fish were fed commercial trout pellets which was discontinued approximaelty 22.5 hours prior to the start of the definitive test. There was no mortality in the 7 days prior to the start of the test and the fish had a mean standard length of 5.5cm ( sd = 0.40) and a mean weight of 1.4g (sd = 0.4) at the end of the definitive test. Based on the mean weight vlaue this gave a loading rate of 0.48g bodyweight/liter ( static volume).
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Test temperature:
- 14-15°C
- pH:
- Fresh media control pH range 7.6 - 8.1
Nominal concentration 100 pH range 7.9 -8.2 - Dissolved oxygen:
- 9.5mg O2/L
- Nominal and measured concentrations:
- Nominal concentration of 100mg/L was used.
- Details on test conditions:
- At the start of the test seven fish were placed in each test vessel at random, in the test preparations. The vessels were covered to reduce evaporation and maintained at 14-16°C with a photoperiod of 16 hours light and 8 hours darkness with a 20 minute dawn and dusk transition. The water temperature, pH and dissolved oxygen concentrations were recorded daily throughout the test, The measurements at 0 hours and after each test media renewal at 24, 48 and 72 hours, represent those of the freshly prepared test preparations. The pH and dissoved oxygen concentrationswere measured using a Hach flex handheld meter, the temperature was measured using a digital thermometer.
- Key result
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Details on results:
- Sub lethal effects of exposure were observed at both the control and 100mg/L test concentrations. These responses inclduing sitting and swimming at the bottom of the tanks.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The acute toxicity of the test item to the freshwater fish rainbow trout (Oncorhynchus mykiss) has been investigated and nominal test concentrations gave a 96-Hour LC50 of greater than 100 mg/L. The No Observed Effect Concentration was 100 mg/L.
- Executive summary:
Introduction
This study was performed to assess the acute toxicity of the test item to rainbow trout. The method was designed to be compatible with the OECD guideline for testing of chemicals (1992) No 203 "Fish,acute toxicity test" referenced as Method C.1 of commission regulation (EC) no 440/2008.
Results and conclusion
Exposure of the rainbow trout to the test item gave LC50 values based on the nominal test concentrations of > than 100mg/L. The No Observed Effect Concentration was 100mg/L.
Reference
Description of key information
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.