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EC number: 238-518-6 | CAS number: 14513-34-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2001/03/13 - 2001/11/29
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Principles of method if other than guideline:
- There were no deviations from protocol that were considered to have affected the validity of the study. However the following deviation occurred: Air exchange was maintained at a minimum of 15 air changes per hour, not a minimum of 12-15 air changes per hour as stated in the protocol.
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 3-trimethoxysilylpropyl methacrylate
- EC Number:
- 219-785-8
- EC Name:
- 3-trimethoxysilylpropyl methacrylate
- Cas Number:
- 2530-85-0
- Molecular formula:
- C10H20O5Si
- IUPAC Name:
- 3-(Trimethoxysilyl)propyl 2-methylprop-2-enoate
- Details on test material:
- - Name of test material (as cited in study report): Dow Corning Z-6030
- Substance type: Alkoxy-Si
- Physical state: colourless liquid
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Not stated.
- Age at study initiation: 8 to 11 weeks old
- Weight at study initiation: 206 to 237 g
- Housing: Individually housed in cages with wire mesh floors (39x39x20 cm)
- Diet: Standard laboratory diet (RM1(E) SQC, ad libitum
- Water: ad libitum
- Acclimation period: minimum of 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.5 to 22°C
- Humidity (%): 35-48%
- Air changes (per hr): minimum of 15
- Photoperiod (hrs dark / hrs light): 12/12 (0600-1800h)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: none
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 1.92 ml/kg bodyweight to achieve a total dosage of approximately 2000 mg/kg
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: The dose level for the study was chosen in compliance with the study guidelines. - Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 3M, 3F
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed on at least two occasions during the first hour following dosing (ca. thirty minutes apart) and thereafter at approximately hourly intervals for the remainder of Day 1 (final observation at 16.00 or 16.20). On subsequent days animals were once in the morning and again at the end of the experimental day (with the exception of Day 15 - morning only). The nature and severity of the clinical signs and time were recorded at each observation. Observations included potential changes in the skin, fur, eyes and mucous membranes, changes in respiratory, circulatory, autonomic, central nervous system, somatomotor activity and behaviour pattern. Particular attention was directed toward the observation of tremors, convulsions, salivation, diarrhoea, lethargy, sleep and coma. The bodyweight of each rat was recorded on days 1 (prior to dosing), 8 and 15. Individual body weights were recorded and bodyweight changes and group means calculated.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: All animals were subjected to a macroscopic examination, which consisted of examination of the cranial, thoracic and abdominal cavities. The macroscopic appearance of all examined organs was recorded. - Statistics:
- Group mean bodyweights were calculated using appropriate means (STRAND version 1.0). No other statistical analyses were carried out.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- There were no treatment related deaths during the study.
- Clinical signs:
- Salivation was seen in all females, immediately after dosing but no clinical signs were seen in males throughout the study. Recovery of the rats as judged by external appearance and behaviour, was complete within approximately one hour of dosing.
- Body weight:
- Low bodyweight gain was recorded for one female on Day 15. All other rats were considered to have achieved satisfactory bodyweight gains during the study.
- Gross pathology:
- There were no abnormalities observed among animals sacrificed at study termination.
- Other findings:
- No other findings were reported.
Any other information on results incl. tables
Under the conditions of this study, the acute LD50 of 3-trimethoxysilylpropyl methacrylate was determined to be greater than 2000 mg/kg body weight.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute lethal oral dose was determined to be >2000 mg/kg bw in a reliable study conducted according to the appropriate test protocol, and in compliance with GLP.
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