4-(5-Ethyl-tetrahydropyran-2-yl)-phenol

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

24.11.2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)

GLP compliance:

no

Type of method:

Laser scattering/diffraction

Type of distribution:

volumetric distribution

Key result

Percentile:

D10

Mean:

5.8 µm

Remarks on result:

other: no SD indicated

Key result

Percentile:

D50

Mean:

48 µm

Remarks on result:

other: no SD indicated

Key result

Percentile:

D90

Mean:

832 µm

Remarks on result:

other: no SD indicated

The test item consisted of agglomerated opaque particles. The test item was sieved with a mesh size of 1000 µm. 48.7 % (w/w) of the test item passed the sieve and only this fraction was measured with laser diffraction.

The particles were introduced to the analyser beam by the dry powder feeder by direct spraying through the measurement aera. The powder was loosened by an integrated vibrator. The particles were dispersed and fed to the optical system by pressurized dry air (1.5 bar). After passing the analyser beam the sample was collected in a vacuum cleaner.

After adjusting the laser, measuring the background and adjusting the correct particle concentration (obscuration) the measurement was started. The control software automatically performed three measurements. The average of these three measurements was given as result. Two test series of three measurements each were performed. The measurement time was 8 s.

For each test series fractions (left axis of the ordinate) and the siftings (right axis of the ordinate) are presented in percent by volume as a function of the particle size. Median values were calculated from unrounded values.

 

The median particle size L50(D (v, 0.5): 50 % of particle volume or particle mass with lower particle diameter) deduced from these distributions were:

1sttest series: L50= 46.6 μm

2ndtest series: L50= 49.4 μm

The average of the median particle size L50was: L50= 48.0 μm

 

The particle size L10 (D (v, 0.1 ): 10 % of particle volume or particle mass with lower particle diameter) deduced from these distributions were:

1sttest series: L10= 5.9 μm

2ndtest series: L10= 5.7 μm

The average of the particle size L10was: L10= 5.8 μm

 

The particle size L90(D (v, 0.9): 90 % of particle volume or particle mass with lower particle diameter) deduced from these distributions were:

1sttest series: L90= 840.9 μm

2ndtest series: L90= 823.2 μm

The average of the particle size L90was: L90= 832.1 μm

 

The particle size distribution showed a polymodal distribution. Maxima were observed at approximately 1 µm, 10 µm and 500 µm.

Conclusions:

The median particle size L50 of the test item deduced from the particle size distributions was 48 μm.

Executive summary:

The determination of the particle size distribution by laser diffraction of the test item was performed according to the OECD Guideline 110 by laser diffraction. The median particle size L50 of the test item deduced from the particle size distributions was 48 μm.

Description of key information

The determination of the particle size distribution by laser diffraction of the test item was performed according to the OECD Guideline 110 by laser diffraction. The median particle size L50 of the test item deduced from the particle size distributions was 48 μm.