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EC number: 258-887-7 | CAS number: 53956-04-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Due to surfactant properties of the test item, the water solubility could not be accurately determinated
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- Due to surfactant properties of the test item, the water solubility could not be accurately determinated
- Principles of method if other than guideline:
- Litterature references:
- KONDO, M. et al. Physicochemical properties and applications of a-and ß-glycyrrhizins, natural surface active agents in licorice root extract. J. Soc. Cosmet. Chem. 37, 177–189 (1986).
- Wang, Y. G., Dai, X. X., Shi, X. Y. & Qiao, Y. J. The simulation on self-aggregated glycyrrhizin structures. Int. J. Appl. Math. Stat. 50, 272–279 (2013).
- Matsuoka, K., Miyajima, R., Ishida, Y., Karasawa, S. & Yoshimura, T. Aggregate formation of glycyrrhizic acid. Colloids Surf. Physicochem. Eng. Asp. 500, 112–117 (2016). - GLP compliance:
- yes
- Type of method:
- flask method
Test material
- Reference substance name:
- Ammonium glycyrrhizate
- EC Number:
- 258-887-7
- EC Name:
- Ammonium glycyrrhizate
- Cas Number:
- 53956-04-0
- Molecular formula:
- C42H65NO16
- IUPAC Name:
- ammonium glycyrrhizate
Constituent 1
Results and discussion
Water solubilityopen allclose all
- Key result
- Water solubility:
- 5 g/L
- Temp.:
- 30 °C
- pH:
- >= 3.5 - <= 5
- Remarks on result:
- completely miscible
- Remarks:
- Due to surfactant properties of the test item, the water solubility could not be accurately determinated. See justification below.
- Key result
- Water solubility:
- >= 0.16 - <= 4.4 g/L
- pH:
- <= 6
- Remarks on result:
- other: critical micelle concentrations (CMC) found in the literature, measured from the glycyrrhizic acid; temperature unknown
Any other information on results incl. tables
A preliminary test was carried out as a range finding test prior to the main test. The concentration range obtained gives an an approximate water solubility of 1.0 g/L. During the main test, the test item concentration at the end of the experiment was around 5 g/L, corresponding to the maximum reachable concentration (loading rate). All the introduced test item was therefore solubilized, the systems were not in the presence of an excess of test item anymore. The test item water solubility could not be determined due to the complete solubilisation of the test item.
These results are contradictory with those obtained during the preliminary test. However, an incubation step at 30°C for 24h was carried out during the main test whereas the mixture was shaken for 10 min at ambient temperature during the preliminary test. This longer incubation period may have allowed the formation of aggregates due to the physicochemical properties of the molecule.
Indeed, surfactant properties have been described in the literature for this test item (see section 4.10).
Applicant's summary and conclusion
- Conclusions:
- The water solubility of the test item could not be accurately determined according to the OECD method 105 due to surface-active properties.
The water solubility of this surfactant test item can be considered as its CMC (critical micelle concentration). Based on both the litterature and the experimental results, the CMC is considered to range 0.16 – 5 g/L depending on the pH of the solution.
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