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EC number: 911-418-6 | CAS number: 55965-84-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
- Objective of study:
- absorption
- distribution
- excretion
- metabolism
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 417 (Toxicokinetics)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.7485 (Metabolism and Pharmacokinetics)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Test material form:
- other: Amber Liquid
- Details on test material:
- - Name of test material (as cited in study report): Kathon™ 886
- Physical state: Amber liquid
- Stability under test conditions: stable at room temperature
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Rohm and Haas, Batch No. 1018.0012 (14C-CMIT), 8001J123 (12C-MIT) and 0000371525 (non-labeled Kathon™ 886F)
RADIOLABELLING INFORMATION (if applicable)
- Radiochemical purity: 99.9%
- Specific activity: 51.65 mCi/g
- Locations of the label: 14C 4,5
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Radiolabeled material was stored at ca. -20°C in a tightly closed container. Non-radiolabeled material was stored in a refrigerator.
- Stability under test conditions: Stable
- Solubility and stability of the test substance in the solvent/vehicle: Soluble and stable
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: Not applicable
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: Dissolution in water
- Preliminary purification step (if any): No
- Final dilution of a dissolved solid, stock liquid or gel: 0.5, 1.5 and 3 mg/mL
FORM AS APPLIED IN THE TEST (if different from that of starting material)
Liquid
OTHER SPECIFICS: Purity of non-labeled test material was 51.4% (Batch No. 8001J123) and 14.11%, of which 10.45% CMIT and 3.66% MIT (Batch No. 0000371525). Test substance was equivalent to Kathon™ 886F with 14C-labelled CMIT. - Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hilltop Lab Animals, Inc. (Scottsdale, Pennsylvania, USA)
- Age at study initiation: 8-10 weeks old
- Weight at study initiation: 232-265 g
- Housing: Stainless steel metabolic cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: ca. 24 h
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-25 °C
- Humidity (%): 50 +/- 20 %
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): 12h/12h
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Duration and frequency of treatment / exposure:
- Single dose and 96 h of exposure
Doses / concentrationsopen allclose all
- Dose / conc.:
- 3.75 mg/kg bw (total dose)
- Remarks:
- Low dose, males/females
- Dose / conc.:
- 11.25 mg/kg bw (total dose)
- Remarks:
- High dose, females
- Dose / conc.:
- 22.5 mg/kg bw (total dose)
- Remarks:
- High dose, males
- No. of animals per sex per dose / concentration:
- 4
- Control animals:
- yes
- Details on dosing and sampling:
- TOXICOKINETIC / PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled (delete / add / specify): urine, faeces and selected tissues: whole blood, plasma, liver, fat, kidneys, bone marrow (femur bone), heart, lungs, brain, testes (male), ovaries (female), muscle (hind leg), spleen, adrenals, thyroids and remaining carcass.
- Time and frequency of sampling: Rats were killed at 96 h post-dose. Urine, cage rinse, and faeces were collected from rats at 24 h intervals for a total of 96 hours. Selected tissues were collected fom all animals in all groups.
METABOLITE CHARACTERISATION STUDIES
- Tissues and body fluids sampled (delete / add / specify): urine, faeces, cage rinse
- Time and frequency of sampling: Every 24 h up to 96 h
- From how many animals: all animals
- Method type(s) for identification: HPLC-UV, Liquid scintillation counting
Results and discussion
Main ADME resultsopen allclose all
- Type:
- excretion
- Results:
- 14C-CMIT-derived 14C-label was rapidly and extensively excreted in the urine and faeces following oral administration
- Type:
- metabolism
- Results:
- 14C-CMIT-derived 14C-label is extensively metabolized
- Type:
- distribution
- Results:
- Tissues contained 0.93-1.44% (female and male, respectively) of dosed radioactivity in the low dose group and 3.94-4.72% (female and male, respectively) in the high dose group.
Toxicokinetic / pharmacokinetic studies
- Details on distribution in tissues:
- Tissues contained 0.93-1.44% (female and male, respectively) of dosed radioactivity in the low dose group and 3.94-4.72% (female and male, respectively) in the high dose group. The highest amount of radioactivity was found in blood, particularly in red blood cells (0.67-1.09% of the dose in the low dose group, and 3.41-4.11% in the high dose group), followed by muscle (0.15%) in low dose group, and by muscle and liver (0.25%) in high dose group.
- Details on excretion:
- 14C-CMIT-derived 14C-label was rapidly and extensively excreted in the urine and faeces following oral administration. A majority of the radioactivity was excreted from the rats in 24 hour (77-87%). Renal and fecal routes of elimination were equally important.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- 14C-CMIT-derived 14C-label is extensively metabolized. Approximately twenty-nine radioactive components were observed in urine and faeces samples from the HPLC radioprofiling. Among these N-methyl malonamic acid was detected as the major component in the urine (15.35-18.19%). 3-mercapturic acid conjugate of 3-sulfinyl-N-methyl-propionamide was detected as the major component in the feces (up to 32.54%). All other metabolites accounted for less than 5% of the dose. Metabolites are thought to result from reduction and oxidation reactions involving phase I enzymes followed by conjugation to glutathione, giving rise to conjugates to glutathione or to mercapturic acid.
Applicant's summary and conclusion
- Conclusions:
- 14C-CMIT-derived 14C-label was rapidly and extensively excreted in the urine and faeces following oral administration. A majority of the radioactivity was excreted from the rats in 24 hour (77-87%). Renal and fecal routes of elimination were equally important. Tissues contained 0.93-1.44% of dosed radioactivity in the low dose group and 3.94-4.72% in the high dose group. Total mean recovery of radioactivity ranged from 85.73 - 95.60%. Gender differences in excretion appeared to be minimal.
- Executive summary:
- This study fulfills the requirements for an OECD 417 and OPPTS 870.7485 Toxicokinetic study. There were no guideline deviations. 14C-CMIT-derived 14C-label was rapidly and extensively excreted in the urine and faeces following oral administration. A majority of the radioactivity was excreted from the rats in 24 hour (77-87%). Renal and fecal routes of elimination were equally important. Tissues contained 0.93-1.44% (female and male, respectively) of dosed radioactivity in the low dose group and 3.94-4.72% (female and male, respectively) in the high dose group. The highest amount of radioactivity was found in blood, particularly in red blood cells (0.67-1.09% of the dose in the low dose group, and 3.41-4.11% in the high dose group), followed by muscle (0.15%) in low dose group, and by muscle and liver (0.25%) in high dose group. Total mean recovery of radioactivity ranged from 85.73 - 95.60%. Gender differences in excretion appeared to be minimal. 14C-CMIT-derived14C-labelis extensively metabolized.Approximately twenty-nine radioactive components were observed in urine and faeces samples from the HPLC radioprofiling. Among these N-methyl malonamic acid was detected as the major component in the urine (15.35-18.19%). 3 -mercapturic acid conjugate of 3 -sulfinyl-N-methyl-propionamide was detected as the major component in the feces (up to 32.54%). All other metabolites accounted for less than 5% of the dose. Metabolites are thought to result from reduction and oxidation reactions involving phase I enzymes followed by conjugation to glutathione,giving rise to conjugates to glutathione or to mercapturic acid.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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