Registration Dossier

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
publication
Title:
IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC RISKS TO HUMANS Volume 108
Author:
IARC
Year:
2016
Bibliographic source:
http://monographs.iarc.fr/ENG/Monographs/vol108/mono108.pdf

Materials and methods

Results and discussion

Applicant's summary and conclusion

Conclusions:
In male Wistar rats, oral administration of aloin A (barbaloin; 100 mg/kg bw) resulted in maximum serum concentrations of aloin A [340 ng/mL; ~0.8 μM, based upon the molecular weight of aloin A of 404 Da] 1.5 hours after administration, followed by a decrease in concentration, with aloin A still detectable 6 hours after dosing.
The ability to cleave anthrone C-glycosides varies among species; free anthrones are detected in faecal contents from humans and rats, but not mice or guinea-pigs.