Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 215-808-0 | CAS number: 1415-73-2
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC RISKS TO HUMANS Volume 108
- Author:
- IARC
- Year:
- 2 016
- Bibliographic source:
- http://monographs.iarc.fr/ENG/Monographs/vol108/mono108.pdf
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- In male Wistar rats, oral administration of aloin A (barbaloin; 100 mg/kg bw) resulted in maximum serum concentrations of aloin A [340 ng/mL; ~0.8 μM, based upon the molecular weight of aloin A of 404 Da] 1.5 hours after administration, followed by a decrease in concentration, with aloin A still detectable 6 hours after dosing.
The ability to cleave anthrone C-glycosides varies among species; free anthrones are detected in faecal contents from humans and rats, but not mice or guinea-pigs.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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