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EC number: 202-594-9 | CAS number: 97-61-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles; method used is similar to OECD TG 301 D (closed bottle test)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- yes
- Remarks:
- ; pre-guidelin study, no duplicates, limited reporting
- Principles of method if other than guideline:
- Tests were performed similar to the method of OECD TG 301 D - Closed Bottle Test. The consumption of dissolved oxygen was measured using a polarographic electrode. Aim of the study was to compare the biodegradability of a variety of chemical substances. Amongst others, biodegradability of linear and branched saturated aliphatic carboxylic acids was investigated.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-methylvaleric acid
- EC Number:
- 202-594-9
- EC Name:
- 2-methylvaleric acid
- Cas Number:
- 97-61-0
- Molecular formula:
- C6H12O2
- IUPAC Name:
- 2-methylpentanoic acid
- Details on test material:
- - Name of test material (as cited in study report): 2-methylvaleric acid
- Source: K & K Laboratories
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): domestic sewage, not further specified
- Method of cultivation: raw sewage was stored at 25°C for 24 to 48 hr prior to use
- Preparation of inoculum for exposure: sewage was filtered through cotton - Duration of test (contact time):
- 10 d
Initial test substance concentration
- Initial conc.:
- 2 other: mg Carbon/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: American Public Health Association (1965) Standard methods for the examination of water and wastewater, 12th edition. American Public Health Association, New York
- Additional substrate: glucose in a second series of experiments to test for toxicity of test substances
- Test temperature: 25°C
- pH: 6.5 - 7.5
- pH adjusted: yes
- Aeration of dilution water: no data
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: 300 mL BOD bottles
- Measuring equipment: oxygen electrode
SAMPLING
- Sampling frequency: none; electrodic oxygen measurements in test flasks
Results and discussion
- Test performance:
- Carboxylic acids and methyl-substituted carboxylic acids including isovaleric acid were readily metabolised
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- 71.8
- Sampling time:
- 10 d
- Remarks on result:
- other: % O2 consumption of ThOD
- Details on results:
- Oxygen consumption (mg/L) BOD (mg O2/mg Substance) % Degr. (BOD/ThOD)
Day 2: 3.5 1.0856 49.3
Day 5: 4.8 1.4888 67.6
Day 10: 5.1 1.5813 71.8
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Based on the oxygen consumption, 2-methylvaleric acid is rapidly biodegraded.
- Executive summary:
The biodegradability of 2-methylvaleric acid and numerous related substances (aliphatic acids and alcohols) was determined in a pre-guideline study. Reporting is limited but the test procedure follows in general the method of OECD TG 301 D (Closed Bottle Test).
Non-adapted sewage of a domestic sewage treatment plant served as inoculum. Test substance was incubated for 10 days at 25°C in the dark. No parallels were set up. Dissolved oxygen was measured at three time points (2, 5, and 10 days).
After 10 days, 2-methylvaleric acid was degraded to ca. 72% (day 5: ca. 68%) (calculated from the originally reported data of oxygen consumption). Based on the oxygen consumption data, 2-methylvaleric acid is readily biodegradable (Dias and Alexander, 1971).
This pre-guideline study provides evidence that aliphatic alcohols and acids (linear and methyl-substituted are rapidly biodegraded. Results are estimated to adequately represent the biodegradability of these substances.
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