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EC number: 210-288-1 | CAS number: 611-99-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- three hours contact time
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test (Carbon and Ammonium Oxidation))
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Lot/Batch number: 20111104
Sponsor: Victrex Manufacturing Ltd
Date of receipt: 01 June 2017
Expiry date: 31 December 2017
Percentage composition and CAS no: Purity => 99.5%. CAS # 611-99-4 - Vehicle:
- no
- Details on test solutions:
- Since the test substance was of limited solubility concentrations of 10, 32, 100, 320 and 1000mg/l were prepared by direct addition into the test vessels.
The pH was measured on the day prior to the definitive test in sacrificial beakers (containing test material, sewage feed and high purity deionised water but without sludge inoculum). Values of 7.41, 7.40, 7.40, 7.39 and 7.39 were recorded for 10, 32, 100, 320 and 1000mg/l respectively. - Test organisms (species):
- activated sludge
- Details on inoculum:
- The day before the test, activated sludge was taken from an aeration tank of Cambridge Sewage Treatment Works (STW), Cowley Road, Cambridge, UK..
The sludge was sieved using an 850μm sieve and centrifuged at about 4000rpm for about ten minutes. The supernatant was discarded and the sludge was resuspended in dechlorinated tap water and re-centrifuged. This stage was repeated once more. After discarding the supernatant the sludge solids were homogenised thoroughly by mechanical stirring (spoon). - Test type:
- static
- Water media type:
- other: High purity deionised water
- Total exposure duration:
- 3 h
- Test temperature:
- Required temperature: 20 ± 2°C
Actual temperature: 21.4– 21.5°C (preliminary test), 21.8 – 21.9°C (definitive) - Reference substance (positive control):
- yes
- Remarks:
- A 1g/l stock of 3,5-Dichlorophenol was prepared in dilution water.
- Key result
- Duration:
- 3 h
- Dose descriptor:
- other: EC20
- Effect conc.:
- 54 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- inhibition of total respiration
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- 162 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- inhibition of total respiration
- Key result
- Duration:
- 3 h
- Dose descriptor:
- other: EC80
- Effect conc.:
- 602 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- inhibition of total respiration
- Key result
- Duration:
- 3 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- inhibition of total respiration
- Details on results:
- ECx values calculated by linear interpolation in ToxCalc™ Version 5.0, 95% confidence limits are shown here
4,4-Dihydroxybenzophenone; EC20 = 54 (48-60), EC50 = 162 (143-176), EC80 = 602 (480-674) - Results with reference substance (positive control):
- 3,5-DCP (Reference) EC20 = 0.98 (0.87-1.18), EC50= 3.59 (2.90-4.69), EC80 = 17.54
- Validity criteria fulfilled:
- yes
- Conclusions:
- The study was conducted according to the test guideline. In the preliminary test, 4,4-Dihydroxybenzophenone exhibited respiration inhibition and a dose response was observed. 4,4-Dihydroxybenzophenone also demonstrated no abiotic response.
The 3-hour EC50 of 4,4-Dihydroxybenzophenone to activated sludge respiration inhibition was determined to be 162mg/l with 95% confidence limits of (143-176mg/l) during the definitive test.
The NOEC for 4,4-Dihydroxybenzophenone was determined to be 10mg/l.
As there was no significant oxygen uptake in the preliminary test abiotic controls were not performed in the definitive test.
Reference
Description of key information
The study was conducted according to the test guideline. In the preliminary test, 4,4-Dihydroxybenzophenone exhibited respiration inhibition and a dose response was observed. 4,4-Dihydroxybenzophenone also demonstrated no abiotic response.
The 3-hour EC50 of 4,4-Dihydroxybenzophenone to activated sludge respiration inhibition was determined to be 162mg/l with 95% confidence limits of (143-176mg/l) during the definitive test.
The NOEC for 4,4-Dihydroxybenzophenone was determined to be 10mg/l.
As there was no significant oxygen uptake in the preliminary test abiotic controls were not performed in the definitive test.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 162 mg/L
- EC10 or NOEC for microorganisms:
- 10 mg/L
Additional information
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