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Diss Factsheets
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EC number: 203-517-1 | CAS number: 107-74-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The single oral dosing of rats with 5 mL/kg of the test item caused no mortality or any visible toxic effects. As this dose level did not produce a toxic effect, a complete LD50 study was not performed.
The single dermal dosing of rabbits with 5 mL/kg bw of the test item caused no mortality or any visible toxic effects, except of mild erythema. As this dose level did not produce a toxic effect, a complete LD50 study was not performed.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1972-1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Normal, healthy rats of the Charles River strain, equally divided as to sex and weighing 200 to 300 grams, were used in this study. The animals were fasted for eighteen hours prior to dosing. The test material was fed as received. A rigid stomach tube was employed for the dosing.
Following the administration of the test material the animals were observed for fourteen days for signs of toxicity. Throughout the observation period the animals were housed in raised wire mesh cages in an air conditioned room. They were fed their regular diet of Lab Blox and water ad libitum. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Specific details on test material used for the study:
- Name: Hydroxycitronellol
Batch: E. O. A. # 72-128 / 5-25-72 - Species:
- rat
- Strain:
- other: Charles River
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Normal, healthy rats of the Charles River strain, equally divided as to sex and weighing 200 to 300 grams, were used in this study. The animals were fasted for eighteen hours prior to dosing. The test material was fed as received. A rigid stomach tube was employed for the dosing.
Following the administration of the test material the animals were observed for fourteen days for signs of toxicity. Throughout the observation period the animals were housed in raised wire mesh cages in an air conditioned room. They were fed their regular diet of Lab Blox and water ad libitum. - Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- not further specified
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5 m / 5 f
- Control animals:
- not specified
- Details on study design:
- The animals were fasted for eighteen hours prior to dosing. Following the administration of the test material the animals were observed for fourteen days for signs of toxicity.
- Statistics:
- not further specified
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- The dosing caused no mortality.
- Clinical signs:
- The dosing caused no adverse effects.
- Body weight:
- The dosing caused no adverse effects.
- Gross pathology:
- not further specified
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The LD50 was greater as 5 mL/kg bw.
- Executive summary:
The single oral dosing of rats with 5 mL/kg of the test item caused no mortality or any visible toxic effects. As this dose level did not produce a toxic effect, a complete LD50 study was not performed.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- Due to animal welfare a further experimental study with exposure of test animals via inhalation is not adequate as valid acute studies with oral and dermal dosing are available. Furthermore, inhalation is not considered to be a relevant pathway for potential human exposure to the test item.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1972-1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Four normal, healthy, albino rabbits, weighing 2 to 3. 5 kilo, were used in this study. The animals had been acclimated to laboratory conditions for at least two weeks prior to being placed on test. Prior to placing the animals on test their backs were clipped free of all hair with small animal clippers. The backs were further prepared by making epidermal abrasions every two to three centimeters, longitudinally, over the clipped area of exposure. The abrasions were sufficiently depp so that they penetrated the stratum corneum but not the dermis, so that no bleeding occurred.
The test material, at a level of 5 ml. per kilo, was applied to the clipped intact and abraded skin areas. These areas were covered with a rubber sleeve or dam which fit snuggly around each animal. The animals were then placed in a multiple animal holder and held there for a twenty-four hour period. During this time each test animal was allowed its daily ration of rabbit pellets and water. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Specific details on test material used for the study:
- Name: Hydroxycitronellol
Batch: E. O. A. # 72-128 / 5-25-72 - Species:
- rabbit
- Strain:
- other: Albino
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Four normal, healthy, albino rabbits, weighing 2 to 3. 5 kilo, were used in this study. The animals had been acclimated to laboratory conditions for at least two weeks prior to being placed on test.
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24
- Doses:
- 5 mL/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- Following the twenty-four hour exposure period the rubber sleeves were removed from the test animals and skin reactions recorded.
Each animal was thoroughly wiped down and returned to its own metabolism cage to be observed for a fourteen day period. - Statistics:
- not further specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- No deaths occurred at a level of 5 ml. per kilo.
- Clinical signs:
- All the animals showed a mild erythema on both the intact and abraded areas.
- Body weight:
- The dosing caused no adverse effects.
- Gross pathology:
- not further specified
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The LD50 was greater as 5 mL/kg bw.
- Executive summary:
The single dermal dosing of rabbits with 5 mL/kg bw of the test item caused no mortality or any visible toxic effects, except of mild erythema. As this dose level did not produce a toxic effect, a complete LD50 study was not performed.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Justification for classification or non-classification
The single oral dosing of rats with 5 mL/kg of the test item caused no mortality or any visible toxic effects. As this dose level did not produce a toxic effect, a complete LD50 study was not performed.
The single dermal dosing of rabbits with 5 mL/kg bw of the test item caused no mortality or any visible toxic effects, except of mild erythema. As this dose level did not produce a toxic effect, a complete LD50 study was not performed.
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