Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 618-690-2 | CAS number: 90982-32-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to birds
Administrative data
- Endpoint:
- long-term toxicity to birds: reproduction test
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Quail were exposed to the appropriate dietary concentrations for five days, and then maintained on basal (toxicant-free) diet for an additional three-day observation period. The control birds received the basal diet with 2% w/w corn oil for the five day exposure period, and basal diet only for the three day observation period.
Symptoms of toxicity and mortality were recorded daily throughout the study. Body weights were recorded by pen at initiation of the study, on Day 5, and at the termination of the study on Day 8. Feed consumption was recorded by pen during the five-day exposure period and during the three-day observation period. Feed consumption was measured accurately, but is presented as an estimate due to the unavoidable wastage by the birds. - GLP compliance:
- no
Test material
- Reference substance name:
- ethyl 2-({[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]amino}sulfonyl)benzoate
- EC Number:
- 618-690-2
- Cas Number:
- 90982-32-4
- Molecular formula:
- C15H15ClN4O6S
- IUPAC Name:
- ethyl 2-({[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]amino}sulfonyl)benzoate
- Test material form:
- solid: particulate/powder
- Details on test material:
- Purity: 96%
1
- Dose method:
- feed
- Analytical monitoring:
- no
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Colinus virginianus
Study design
- Total exposure duration (if not single dose):
- 8 d
- Post exposure observation period:
- 3 d
- No. of animals per sex per dose and/or stage:
- 10
- Control animals:
- yes, plain diet
- Nominal and measured doses / concentrations:
- 562, 1000, 1780, 3160, and 5620 ppm
Examinations
- Reference substance (positive control):
- yes
- Remarks:
- Dieldrin
Results and discussion
Effect levels
- Duration (if not single dose):
- 8 d
- Dose descriptor:
- LC50
- Effect level:
- > 5 620 other: ppm
- Conc. / dose based on:
- test mat.
- Basis for effect:
- mortality
- Mortality and sub-lethal effects:
- There was no mortality in any of the control or test birds
- Results with reference substance (positive control):
- The most recent positive control with dieldrin, run on January 13, 1983, yielded an LC50 value of 30 ppm, with confidence limits of 25 ppm to 36 ppm. This falls within two standard deviations of the historical positive control values from studies run since July 12, 1977 of 38 ppm ± 5 ppm (SD).
Any other information on results incl. tables
Body weight and estimated feed consumption of bobwhite quail exposed to DPX-F6025 for five days
Concentration of DPX-F6025 |
Average body weight on day 0 |
Average body weight on day 5 |
Average body weight on day 8 |
Feed consumption (F.C.) Days 0-5 |
Feed consumption (F.C.) Days 6-8 |
F.C./bird/day (Days 0-5) |
F.C./bird/day (Days 6-8) |
0 |
27 g |
39 g |
47 g |
425 g |
308 g |
9 |
10 |
0 |
27 g |
40 g |
48 g |
552 g |
303 g |
11 |
10 |
0 |
30 g |
43 g |
52 g |
521 g |
306 g |
10 |
10 |
0 |
30 g |
45 g |
52 g |
454 g |
326 g |
9 |
11 |
0 |
27 g |
40 g |
48 g |
472 g |
280 g |
9 |
9 |
562 ppm |
29 g |
44 g |
53 g |
379 g |
249 g |
8 |
8 |
1000 ppm |
30 g |
46 g |
55 g |
414 g |
254 g |
8 |
8 |
1780 ppm |
30 g |
44 g |
53 g |
413 g |
292 g |
8 |
10 |
3160 ppm |
32 g |
46 g |
55 g |
469 g |
274 g |
9 |
9 |
5620 ppm |
31 g |
46 g |
56 g |
447 g |
313 g |
9 |
10 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- no
- Conclusions:
- The test substance did not cause overt symptoms of toxicity or behavioral abnormalities at any concentration level tested. There were no mortalities at any concentration level tested. There appeared to be a slight reduction in feed consumption at the 562 ppm through 1780 ppm concentration levels for the first five days of the study and a slight reduction in feed consumption at 562 ppm and 1000 ppm concentration levels for the final three days of the study. There was no effect on body weight gain at any concentration level.
- Executive summary:
Quail were exposed to the appropriate dietary concentrations for five days, and then maintained on basal (toxicant-free) diet for an additional three-day observation period. The control birds received the basal diet with 2% w/w corn oil for the five day exposure period, and basal diet only for the three day observation period.
The test substance did not cause overt symptoms of toxicity or behavioral abnormalities at any concentration level tested. There were no mortalities at any concentration level tested. There appeared to be a slight reduction in feed consumption at the 562 ppm through 1780 ppm concentration levels for the first five days of the study and a slightreduction in feed consumption at 562 ppm and 1000 ppm concentration levels for the final three days of the study. There was no effect on body weight gain at any concentration level.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.