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Diss Factsheets
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EC number: 229-765-0 | CAS number: 6713-03-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 11 September 2017 to 29 September 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Freshwater Alga and Cyanobacteria, Growth Inhibition Test)
- Deviations:
- yes
- Remarks:
- The 24h growth rates were not used in the calculation of results.
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- TEST ORGANISM
- Common name: Pseudokirchneriella subcapitata
- Strain: 278/4
- Source (laboratory, culture collection): SAMS Limited
- Age of inoculum (at test initiation):
- Method of cultivation: culture were prepared from stock laboratory cultures by inoculating autoclaved freshwater at 120 °C for 15 minutes with nutrient medium (3N-BBM+V) 2 to 4 days before test commencement and incubated at approximately 21 2 °C under constant illumination as the inoculum source for subsequent toxicity tests.
ACCLIMATION
- Culturing media and conditions: same as test
- Any deformed or abnormal cells observed: None reported - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Hardness:
- Not specified
- Test temperature:
- 21 to 24 °C
- pH:
- 8.1 ±0.2. Not increased during the test by more than 1.5 relative to the pH of the growth medium.
- Dissolved oxygen:
- Not specified
- Salinity:
- Not specified
- Conductivity:
- Not specified
- Nominal and measured concentrations:
- Nominal concentrations: 1, 10, 100, and 1000 mg/L.
- Details on test conditions:
- TEST SYSTEM
- Test vessel: borosilicate glass crystallising dishes
- Material, size, headspace, fill volume: 100 mL
- Type of flow-through: static
- Initial cells density: initial cell density of approximately 5 x10^3-10^4 cells per millilitre
- No. of vessels per concentration (replicates): three
- No. of vessels per control (replicates): six
GROWTH MEDIUM
- Standard medium used: yes
- Detailed composition if non-standard medium was used: As specified in OECD 201
OTHER TEST CONDITIONS
- Light intensity and quality: Between 5470 and 5490 lx
TEST CONCENTRATIONS
- Test concentrations: 1, 10, 100 and 1,000 mg/L - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 5 600 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Details on results:
- - Exponential growth in the control (for algal test): yes
- Observation of abnormalities (for algal test): None reported
- Unusual cell shape: None reported
- Colour differences: None reported
- Flocculation: None reported
- Adherence to test vessels: None reported
- Aggregation of algal cells: None reported
- Any stimulation of growth found in any treatment: None reported
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: None reported
- Effect concentrations exceeding solubility of substance in test medium: no - Results with reference substance (positive control):
- - Results with reference substance valid? yes
- EC50: 1.42 mg/L - Reported statistics and error estimates:
- Results for both range-finding and definitive tests were calculated by Linear Interpolation within the CETIS suite of statistical analysis.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 72-hour EC50 was >10,000 mg/L and the 72-hour NOEC 5,600 mg/L. The substance did not meet the criteria for classification as toxic to the aquatic environment according to Regulation (EC) N° 1272/2008.
- Executive summary:
The short-term toxicity of 1-[(2-hydroxyethyl)thio]propan-2-ol to algae was determined during a GLP-compliant study performed according to the OECD Testing Guideline 201.
The species was Pseudokirchneriella subcapitata.
A range-finding test was performed to determine the concentrations to be used during the definitive test. As a result of this range-finding test, concentrations of 1,000, 1,800, 3,200, 5,600 and 10,000 mg/L were used during the definitive test.
The 72-hour EC50 was >10,000 mg/L and the 72-hour NOEC 5,600 mg/L. The substance did not meet the criteria for classification as toxic to the aquatic environment according to Regulation (EC) N° 1272/2008.
Reference
Description of key information
The short-term toxicity of 1-[(2-hydroxyethyl)thio]propan-2-ol to algae was determined during a GLP-compliant study performed according to the OECD Testing Guideline 201.
The species was Pseudokirchneriella subcapitata.
A range-finding test was performed to determine the concentrations to be used during the definitive test. As a result of this range-finding test, concentrations of 1,000, 1,800, 3,200, 5,600 and 10,000 mg/L were used during the definitive test.
The 72-hour EC50 was >10,000 mg/L and the 72-hour NOEC 5,600 mg/L. As a conclusion the test substance was not considered to be toxic to aquatic algae and cyanobacteria.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 10 000 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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