Registration Dossier
Registration Dossier
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EC number: 223-026-6 | CAS number: 3697-42-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- 1:6-Di 4-chlorophenyldiguanidohexane (“Hibitane”). Laboratory investigation of a new antibacterial agent of high potency.
- Author:
- Davies GE, Francis J, Martin AR, Rose FL, Swain G
- Year:
- 1 954
- Bibliographic source:
- Brit. J. Pharmacol. Chemother. 9, 192-196
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Remarks:
- study performed prior to implementation of GLP
- Limit test:
- yes
Test material
- Reference substance name:
- Chlorhexidine dihydrochloride
- EC Number:
- 223-026-6
- EC Name:
- Chlorhexidine dihydrochloride
- Cas Number:
- 3697-42-5
- Molecular formula:
- C22H30Cl2N10.2ClH
- IUPAC Name:
- chlorhexidine dihydrochloride
- Test material form:
- not specified
- Details on test material:
- Chlorhexidine dihydrochloride
CHD*2HCl, Charge 900214 vom 27.11.90
Constituent 1
Test animals
- Species:
- mouse
- Details on test animals or test system and environmental conditions:
- Albino mice weighing 16-22 g were dosed once and observed for ten days
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- water
- Doses:
- not specified
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
Applicant's summary and conclusion
- Conclusions:
- In mice, LD50 was >5000 mg/kg after subcutaneous injection.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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