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EC number: 242-358-2 | CAS number: 18479-49-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28th October 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,7-dimethyloct-1-en-3-ol
- EC Number:
- 242-358-2
- EC Name:
- 3,7-dimethyloct-1-en-3-ol
- Cas Number:
- 18479-49-7
- Molecular formula:
- C10H20O
- IUPAC Name:
- 3,7-dimethyloct-1-en-3-ol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 10 animals (5 male, 5 females)
Animal Breeder: DR . K . THOMAE GMBH, D-7950 BIBERACH, FRG
Acclimatization period: at least for 1 week
n. of aniumal per cage: 5
Animals were housed in fully air-conditioned rooms. Temperature range: 20 - 24 Celsius degrees. Relative humidity: 30 - 70%
There were no deviations from these ranges which influenced the results of the study.
Day/Night rhythm: 12 h/12 h (6 .00am-6pm/ 6pm -6 am)
Diet: Kliba-Labordiaet 343, klimgentalmuehle AG CH-4303 Kaiseraugst, Switzerland ad libitum
Drinking water: Tap water ad libitum
Animal weights: animal of comparable weight (+/- 20% of the mean weight)
Feed was not provided to the animals starting from 16 hours before administration but water was maintained available ad libitum.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- Reason for the vehicle: aqueous formulation corresponds to the physiological medium
Form of the administratio: emulsion - Doses:
- Dose (mg/kg): 2000
Concentration (g/100 ml - W/V): 20
Administration volume (ml/kg): 10
Time of the day for the administration: in the morning - No. of animals per sex per dose:
- 10 animals in total (5 male, 5 females)
- Details on study design:
- number of animal per cage: 5
animal identification: by cage cards
Type of cage: STAINLESS STEEL WIRE MESH CAGES,TYPE DK-III ( BECKER & CO .,CASTROP-RAUXEL . FRG )
N. of animals per dose: 5 male animals and 5 female animals
Signs and symptons: OF SIGNS AND SYMPTOMS SEVERAL TIMES ON THE DAY OF ADMINISTRATION, AT LEAST ONCE EACH WORKDAY . CHECK FOR MORIBUND AND DEAD ANIMALS TWICE EACH WORKDAY AND ONCE ON HOLIDAYS .
Pathology: WITHDRAWAL OF FOOD ABOUT 16 HOURS BEFORE SACRIFICE WITH C02 ; THEN NECROPSV WITH GROSS-PATHOLOGICAL EXAMINATION . NECROPSY OF ALL ANIMALS THAT DIE AS EARLY AS POSSIBLE .
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- Dead animals after 14 days: 0
Mortality: 0 %
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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