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EC number: 252-279-5 | CAS number: 34907-26-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation:
Both of the two structurally similar molecules (2,4-dinitrotoluene and 2,6-dichloro-4-nitroaniline) are not classified for irritation. Both also showed the same experimental result of "Not irritating", neither result required the classification as a skin irritant.
Eye irritation:
Two strucutrally similar molecules were used for read-across. The molecule 2,4-dinitrotoluene had an experimental result of "Not Irritating" to the eye whilst 2,6-dichloro-4-nitroaniline had an experimental result of "Mildly Irritating to the eye". Neither result required classification as an ocular irritant.
Based on read-across to the two structurally similar molecules (2,4-dinitrotoluene and 2,6-dichloro-4-nitroaniline) it is assumed the compound N,N,N-trimethyl-nitroanilinium chloride is not a skin or eye irritant, and therefore has no skin sensitization classification under CLP (1272/2008).
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation / corrosion, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Read-across
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- From read-across report
- Justification for type of information:
- See attached for read-across supporting information.
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Results aquired form a JMPR evaluation - guideline followed is not specified in the report.
- GLP compliance:
- not specified
- Remarks:
- Data from collection/ handbook, no informaiton on completion date or compliace is available.
- Specific details on test material used for the study:
- Read-across to 2,6-dichloro-4-nitroaniline (JMPR evaluation)
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- not specified
- Preparation of test site:
- other: abraded or unabraided
- Vehicle:
- water
- Amount / concentration applied:
- 500 mg per site (Raczniak & Wood, 1980b) or after repeated daily applications of 10 mg dry material or 0.1 ml of 10% aqueous suspension to the abraded or unabraded skin of albino rabbits over five days (Boots Pure Drug Co., 1962)
- Irritation parameter:
- other: Final result from read-across molecule
- Basis:
- other: Final result from read-across molecule
- Time point:
- other: Final result from read-across molecule
- Reversibility:
- other: Not irritating (JMPR evaluation)
- Remarks on result:
- no indication of irritation
- Remarks:
- Not irritating (JMPR evaluation)
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The compound 2,6-dichloro-4-nitroaniline was found to be not irritating, and therefore has no irritation classification under CLP (1272/2008)
- Executive summary:
The compound 2,6-dichloro-4-nitroaniline was found to be not irritating, and therefore has no irritation classification under CLP (1272/2008)
- Endpoint:
- skin irritation / corrosion, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Read-across
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- From read-across report
- Justification for type of information:
- See attached for read-across supporting information.
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Carried out according to the modified Draize procedure, Guideline not specified in read across report
- GLP compliance:
- not specified
- Remarks:
- Data from collection/ handbook, no informaiton on completion date or compliace is available.
- Specific details on test material used for the study:
- Not available, read-across fro EU RAR of 2,4-dinitrotoluene
- Species:
- rabbit
- Strain:
- other: New Zealand, colour not specified
- Details on test animals or test system and environmental conditions:
- Zealand rabbits with intact and abraded skin in each test group and control group were used (n= 6/group). After application of the 2,4-DNT as a 50% pasta with peanut oil, all animals were
examined for signs of erythema and oedema, and the responses scored at 24 and 72 hours.
The purity of 2,4-DNT was 98% with 2% of 2,6-DNT as impurity. - Type of coverage:
- not specified
- Preparation of test site:
- abraded
- Vehicle:
- other: peanut oil
- Amount / concentration applied:
- 2,4-DNT as a 50% pasta with peanut oil
- Duration of treatment / exposure:
- Not Specified
- Observation period:
- all animals were examined for signs of erythema and oedema, and the responses scored at 24 and 72 hours.
- Number of animals:
- New Zealand rabbits with intact and abraded skin in each test group and control group were used (n= 6/group).
- Details on study design:
- Carried out according to the modified Draize procedure.
- Irritation parameter:
- other:
- Basis:
- other: Final result from read-across molecule
- Time point:
- other: Final result from read-across molecule
- Reversibility:
- other: Not irritating (EU RAR)
- Remarks on result:
- no indication of irritation
- Remarks:
- Not irritating (EU RAR)
- Irritant / corrosive response data:
- The primary irritation score of 2,4-DNT was 0.25 over control.
- Other effects:
- None noted.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The compound 2,4-dinitrotoluene was found to be not irritating, and therefore has no irritation classification under CLP (1272/2008)
- Executive summary:
The compound 2,4-dinitrotoluene was found to be not irritating, and therefore has no irritation classification under CLP (1272/2008)
Referenceopen allclose all
Technical-grade dicloran (purity, 96%) was not irritating to the intact or abraded skin of male or female New Zealand white rabbits at a concentration of 500 mg per site (Raczniak & Wood, 1980b) or after repeated daily applications of 10 mg dry material or 0.1 ml of 10% aqueous suspension to the abraded or unabraded skin of albino rabbits over five days (Boots Pure Drug Co., 1962).
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Read-across
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- See attached for read-across supporting information.
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- From read-across report utilising 2,6-dichloro-4-nitroaniline JMPR evaluation
- GLP compliance:
- not specified
- Remarks:
- Data from collection/ handbook, no informaiton on completion date or compliace is available.
- Specific details on test material used for the study:
- From read-across report utilising 2,6-dichloro-4-nitroaniline JMPR evaluation
- Irritation parameter:
- other: Final result from read-across report
- Basis:
- other: Final result from read-across report
- Time point:
- other: Final result from read-across report
- Reversibility:
- not specified
- Remarks on result:
- probability of mild irritation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The compound 2,6-dichloro-4-nitroaniline was found to be mildly irritating to the eyes, and therefore has no eye irritation classification under CLP (1272/2008)
- Executive summary:
The compound 2,6-dichloro-4-nitroaniline was found to be mildly irritating to the eyes, and therefore has no eye irritation classification under CLP (1272/2008)
- Endpoint:
- eye irritation, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Read-across
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- See attached for read-across supporting information.
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- From read-across report utilising 2,4-dinitrotoluene EU RAR assessment
- GLP compliance:
- not specified
- Remarks:
- Data from collection/ handbook, no informaiton on completion date or compliace is available.
- Specific details on test material used for the study:
- From read-across report utilising 2,4-dinitrotoluene EU RAR assessment
- Irritation parameter:
- other: Final result from read-across report
- Basis:
- other: Final result from read-across report
- Time point:
- other: Final result from read-across report
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The compound 2,4-dinitrotoluene was found to be not irritating to the eyes, and therefore has no eye irritation classification under CLP (1272/2008)
- Executive summary:
The compound 2,4-dinitrotoluene was found to be not irritating to the eyes, and therefore has no eye irritation classification under CLP (1272/2008)
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Not required on the basis of tonnage
Justification for classification or non-classification
There is sufficient evidence from the two structurally similar molecules (2,4-dinitrotoluene and 2,6-dichloro-4-nitroaniline) to show the compound N,N,N-trimethyl-nitroanilinium chloride should not be a skin or eye irritant, and therefore has no skin or eye irritation classification under CLP (1272/2008).
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