Registration Dossier
Registration Dossier
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EC number: 230-256-0 | CAS number: 6990-06-3
Endpoint summary
Administrative data
Description of key information
Acute toxicity studies are available for fish, invertebrate and algae. Studies are conducted according to OECD guidelines no 203, 202 and 201, respectively and following GLP. For environmental realistic conditions at pH 7-8, fusidic acid will be almost completely (99-100%) dissociated and will be present in the fusidate form. Due to the dissociation of the substance, it is therefore justified to use environmental data on the fusidate form to describe fusidic acid under these conditions.
Fish:
Sodium Fusidate was considered stable throughout the test (recovery was between 101-122%) and results therefore based on nominal concentrations. Validity criteria were fulfilled.
Results did not allow statistical analysis as the highest test concentration (400 mg/L) only resulted in 30% mortality during the exposure period. LC50 fish (96h) is therefore reported as > 400 mg/L.
Invertebrate:
The test was performed with Daphnia magna, as a semi static test (renewal of test solutions after 24 hours). The test substance was considered stable during the test and concentrations were reported as nominal concentrations. The resulting EC10 and EC 50 values for aquatic invertebrates were:
EC10 (48h) = 225 mg/L
EC50 (48h) = 367 mg/L
Algae:
The test was performed with algae (Pseudokirchneriella subcapitata). The test substance was considered stable during the test and results therefore reported as nominal concentrations.
The resulting EC10; EC50 and NOEC values (72h) for aquatic algae were: 0.7 mg/L, 4.3 mg/L and 0.3 mg/L respectively (based on growth rate).
Additional information
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