Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 235-527-7 | CAS number: 12262-58-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Adequate details however 24 hour exposure; no COA; non-GLP. Needs test article id statement
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: USA Federal Hazardous Substances Act (US-FHSA),
- Deviations:
- not specified
- Principles of method if other than guideline:
- USA Federal Hazardous Substances Act (US-FHSA),
- GLP compliance:
- no
Test material
- Reference substance name:
- Cyclohexanone, peroxide
- EC Number:
- 235-527-7
- EC Name:
- Cyclohexanone, peroxide
- Cas Number:
- 12262-58-7
- Molecular formula:
- Multi-constituent substance (equilibrium mixture of a number of cyclohexyl based organic peroxides, hydrogen peroxide, cyclohexanone and water)
- IUPAC Name:
- Peroxycyclohexanone
- Reference substance name:
- Cyclonox LE
- IUPAC Name:
- Cyclonox LE
- Test material form:
- other: colorless liquid
- Details on test material:
- None provided. Only trade name and physical form provided. The purity was not provided. However, it is assumed to be 21% based on the information provided in another acute report, conducted during the same time frame, at the same laboratory.
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- None provided.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: shaved and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 and 72 hours after application
- Number of animals:
- Six rabbits are treated on intact ski and six on abraded skin
- Details on study design:
- Twelve healthy adult New Zealand White albino rabbits are used for 1-4 test substances. Twenty four hours prior to applying the materials, hair is removed from the backs of the animals with an electric clipper in such a way as to avoid abrasions.
An amount of 0.5 ml of the test substance is brought on the intact or abraded skin under a surgical patch measuring 1 inch x 1 inch. The patches are fixed to the application site by means of adhesive tape and the entire trunk of the rabbits is wrapped with an impervious material to maintain the test patches in position and to retard evaporation of volatile substances.
Six rabbits are treated on the intact skin, the other six on the abrades. The abrasions are minor incisions through the stratum corneum, but not sufficiently deep to disturb the derma or the product bleeding.
After an exposure period of 24 hours the patches and the material applied are removed and the resulting skin reactions are evaluated by the method of Draize (J. Pharmacol. 82 (1944) 377-390). A second reading is made 48 hours later (72 hours after application).
In the case of surface active test substances the skin reactions after 72 hours usually consist of scaliness and/or necrosis,. Since the Draize grading system does not comprise these abnormalities the second reading is carried out on the basis of the laboratory's own grading system.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Remarks:
- Erythema plus edema
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 6.7
- Max. score:
- 8
- Reversibility:
- other: No data reported
- Remarks on result:
- other: Intact skin
- Irritation parameter:
- overall irritation score
- Remarks:
- erythema
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 2
- Max. score:
- 8
- Reversibility:
- other: No data reported
- Remarks on result:
- other: intact skin
- Irritation parameter:
- overall irritation score
- Remarks:
- erythema and edema
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 6.8
- Max. score:
- 8
- Reversibility:
- other: No data reported
- Remarks on result:
- other: abraded skin
- Irritation parameter:
- overall irritation score
- Remarks:
- erythema
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 2
- Max. score:
- 8
- Reversibility:
- other: No data reported
- Remarks on result:
- other: abraded skin
- Irritant / corrosive response data:
- After 24 hours: distinct ischemia and slight or moderate edema.
After 72 hours: very slight to distinct scaliness or incrustation.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- The test substance is a severe to very severe primary skin irritant.
- Executive summary:
The test article was evaluated for its potential skin irritation potential. The test article was applied to the intact and abraded skin of rabbits for 24 hours and the reactions scored according to the Draize method 24 and 72 hours following application.
The test article was severely irritating to rabbit skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.