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EC number: 241-300-3 | CAS number: 17265-14-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- - The test substance was added directly into the study beaker.
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Source: Yara Tropical Fish s.r.l., Ivrea
- Length at study initiation: ~ 3 cm
- Weight at study initiation: ~ 0.47 g
ACCLIMATION
- Type and amount of food during acclimation: Sera sikus food
- Feeding frequency during acclimation: daily
FEEDING DURING TEST
No - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- about 228 mg of CaCO3
- Test temperature:
- 20 - 22 °C
- pH:
- 7.1 - 7.9
- Dissolved oxygen:
- 7.0 - 8.9 mg/L
- Nominal and measured concentrations:
- - Nominal test concentration 100 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass beakers (5 L)
- Material: glass
- Renewal rate of test solution (frequency): 24 h
- No. of organisms per vessel: 7
- Biomass loading rate: maximum loading < 1.0 g fish/L (ca. 0.46 g/L)
TEST MEDIUM / WATER PARAMETERS
- Ca/mg ratio: reconstituted water with Ca:Mg rate of 4:1 and a Na:K rate of 10:1
OTHER TEST CONDITIONS
- Photoperiod: artificial lighting, light period 16 h/day - Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- not determinable
- Details on results:
- - Behavioural abnormalities: No animals of the treated group showed visible signs of abnormalities.
- Mortality of control: No animals in the control died.
- Abnormal responses: No animals of the control showed visible signs of abnormalities. - Sublethal observations / clinical signs:
- The values of dissolved oxygen, pH and temperature always remained within the acceptance limits.
- Validity criteria fulfilled:
- yes
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: Paris Commission Guideline (PRACOM 2006): Protocols on Methods for the Testing of Chemicals Used in the Offshore Oil Industry. Part B: Protocol for a Fish Acute Toxicity Test.
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: The test substance was added directly into the aquaria, without using carrier or solvent. The test solutions were stirred for 1 minute. The test substance was stated to be insoluble in water, the amount of test substance added to the water in this way is referred to as nominal concentration, and should not be confused with the actual, but unknown, concentration in the water phase. The solutions were prepared by the same procedure for renewal of the test solutions afte 48 hours. - Test organisms (species):
- other: Scophthalmus maximus
- Details on test organisms:
- TEST ORGANISM
- Common name: turbot
- Source: Animals were hatched 28.07.09 in Denmark, and were transported by car and airplane to Eurofins on 13.11.09
- Length at study initiation (range): 54 - 59 mm
- Weight at study initiation (mean): 3.6 g
ACCLIMATION
- Acclimation conditions: At Eurofins, they were held at a temperature of 16.0°C - Test type:
- semi-static
- Water media type:
- saltwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Test temperature:
- 14.9-15.4 °C
- pH:
- Initial 8.2
- Dissolved oxygen:
- 97 - 99 % saturation
- Salinity:
- 34.4 per mill
- Nominal and measured concentrations:
- Nominal test concentration: 18 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass aquaria
- Fill volume: 10 L
- Aeration: Yes
- Renewal rate of test solution (frequency): 48 h
- No. of organisms per vessel: 7
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Natural seawater from an unpolluted site at about 80 m depths in Byfjord was collected from a tap. The seawater was oxygenated and temperature adjusted, before use as dilution water, control and for acclimation of the fish.
OTHER TEST CONDITIONS
- Photoperiod: 12 h light / 12 h dark
EFFECT PARAMETERS MEASURED
- Lethality (number of dead organisms) was registered daily by visual observation.
- Measurements of oxygen was done daily, temperature was measured at start, while pH and salinity were measured at start, day two and day four.
TEST CONCENTRATIONS
- Justification for using less concentrations than requested by guideline: Limit test - Reference substance (positive control):
- yes
- Remarks:
- 3,5-Dichlorophenol
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 18 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: No mortality was observed and no behavioural abnormalities.
- Mortality of control: < 10 % - Results with reference substance (positive control):
- The percentage mortality in the blank was < 10%, and the 96 hours test result with the 3,5 dichlorphenol turned out to be as expected.
Referenceopen allclose all
Description of key information
No acute toxic effects on fresh or marine water fish were observed (Ausimont, 1999; BASF SE, 2009).
Key value for chemical safety assessment
Additional information
No data on aquatic toxicity with the salt disodium sebacate are available. Only data on the acid are available:
In a 96-h acute toxicity study (BASF SE, 2009), turbot, Scophthalmus maximus were exposed to sebacic acid at nominal limit concentrations of 0 (control) and 18 mg/L under static conditions according to the Paris Commission Guideline [(PRACOM 2006): Protocols on Methods for the Testing of Chemicals Used in the Offshore Oil Industry. Part B: Protocol for a Fish Acute Toxicity Test]. The 96-h LC50 was > 18 mg/L. No sub lethal effects were observed in the groups exposed to 18 mg/L sebacic acid.
In a 96-h acute toxicity study (Ausimont, 1999), zebra fish, Danio rerio were exposed to sebacic acid at a nominal limit concentration of 100 mg/L under semi-static conditions according to OECD Guideline 203. The 96-h LC50 was > 100 mg/L. No sub lethal effects were observed in the groups exposed to 100 mg/L of sebacic acid.
However, according to ECHA guidance R7b effects can be extrapolated from the anion or cation, whichever has the most toxic effect, if no data are available on a salt.
If the effect is related to only one of the ions, the classification of the salt should use the effect concentration multiplied by the salt/ion molecular weight ratio.
The molecular weight ratio between salt and ion is 246 : 202 (1.22)
Based on this correction the LC 50 for disodium sebacate was determined to be 22 mg/L in the test with marine fish and >122mg/L in the test with freshwater fish.
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