Registration Dossier
Registration Dossier
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EC number: 233-465-5 | CAS number: 10191-18-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- in vitro skin irritation
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- A review of taurine and its salts, including those of secondary amines
Work is to support use of these amino acid derivatives in cosmetics
Limited data on the animal work performed historically, but conclusion is that these are not potential for skin irritation
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Safety Assessment of Alkyl Taurate Amides and Taurate Salts as Used in Cosmetics
- Author:
- Cosmetic Ingredient Review
- Year:
- 2 015
- Bibliographic source:
- Cosmetic Ingredient Review, 2015
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Taurine
- EC Number:
- 203-483-8
- EC Name:
- Taurine
- Cas Number:
- 107-35-7
- Molecular formula:
- C2H7NO3S
- IUPAC Name:
- 2-aminoethanesulfonic acid
Constituent 1
- Specific details on test material used for the study:
- Note that the review covers taurine and derivates; testing appears to have been performed on salts, but the review concludes that these can all be groups for evaluation purposes.
In vitro test system
- Test system:
- human skin model
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- water
- Amount / concentration applied:
- 10 mg in 5 µL sterile water to wet the test substance; >90% pure
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- % tissue viability
- Value:
- 100
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- A review of taurine and its salts, including those of secondary amines
Work is to support use of these amino acid derivatives in cosmetics
Limited data on the animal work performed historically, but conclusion is that these are not potential for skin irritation
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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