Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 214-122-9 | CAS number: 1087-21-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Date of Study Report: August 25, 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given: comparable to guidelines/standards
- Justification for type of information:
- ANALOGUE APPROACH JUSTIFICATION
Please refer to attached document.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 16CFR 1500.40
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Diallyl phthalate
- EC Number:
- 205-016-3
- EC Name:
- Diallyl phthalate
- Cas Number:
- 131-17-9
- Molecular formula:
- C14H14O4
- IUPAC Name:
- 1,2-Benzenedicarboxylic acid, di-2-propenyl ester
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Diallyl phthalate
- Analytical purity: 99 %
- Other:
- Identified as C8013-3
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- The acute dermal toxicity study (single exposure) was conducted on adult albino rabbits selected from healthy, acclimated animals.
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- No details provided in report
- Duration of exposure:
- No details provided in report
- Doses:
- 200, 2000 and 5000 mg/kg
- No. of animals per sex per dose:
- 30 rabbits used in total (no details provided whether they were male or female)
- Control animals:
- not specified
- Details on study design:
- No details provided in report
- Statistics:
- No details provided in report
Results and discussion
- Preliminary study:
- N/A
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 300 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No details provided in report
- Clinical signs:
- No details provided in report
- Body weight:
- No details provided in report
- Gross pathology:
- No details provided in report
- Other findings:
- No details provided in report
Any other information on results incl. tables
Results:
Dosage Level (mg/kg) |
No.*Rabbits Dosed |
Deaths |
||||||||||||||
Day |
||||||||||||||||
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
Mortality after 14 Days |
||
200 |
10 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
3/10 |
2000 |
10 |
1 |
0 |
0 |
1 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
1 |
0 |
0 |
4/10 |
5000 |
10 |
1 |
2 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
6/10 |
* Administered as received.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The approximate acute Dermal LD50 obtained for the test material identified above is 3300 mg/kg of body weight estimated by interpolation from the probit response curve.
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