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Diss Factsheets
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EC number: 911-168-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February from 02 to 15, 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- adopted 24th February 1987
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Fluorescent Brightener 219
- IUPAC Name:
- Fluorescent Brightener 219
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG, Kastengrund, SPF-Zucht.
- Age at study initiation: 7 weeks males and 6 weeks females.
- Weight at study initiation: males mean 180 g (173 - 189 g); females mean 167 g (161 - 170 g).
- Fasting period before study: the feed was suspended 16 hours before the treatment and was resumed 3-4 hours after the treatment.
- Housing: fully-air-conditioned rooms, in Makrolon cages (type 4) on limewood granules; groups of 5 animals.
- Diet: standard diet Altromin 1324, ad libitum.
- Water. tap water, ad libitum.
- Acclimation period: at least 5 days.
ENVIRONMENTAL CONDITIONS
- Temperature: 22 ± 3 °C
- Humidity: 50 ± 20 %
- Photoperiod: 12 hours daily.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: strength mash (potato starch in deionized water)
- Details on oral exposure:
- VEHICLE
- Preparation: test item was suspended in a 2 % strength mash (potato starch in deionized water) using a mortar and pestle and homogeneously distributed using a magnetic stirrer.
- Concentration: 20 % (w/w)
- Application volume: 10 ml/kg bw - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 males and 5 females
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weight of the animals was determined weekly.
- Necropsy of survivors performed: yes; at the end of the observation period, the test animals were killed by carbon dioxide, dissected and examined for macroscopically visible changes.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- No death occurred.
- Clinical signs:
- No symptoms occurred during the entire observation period.
- Body weight:
- No impairment of body weight development was recorded.
- Gross pathology:
- The animals at the end of the post-observation period were free of macroscopically visible changes.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified, according to the CLP Regulation ((EC 1272/2008)
- Conclusions:
- LD50 (male and female) > 2000 mg/kg bw
- Executive summary:
The acute oral toxicity potential of test item was investigated according to the procedures outlined into the OECD guideline 401 and according to the EU Method B.1. 5 males and 5 females rats were treated at a dosage level of 2000 mg/kg bw. The test item was suspended in a 2 % strength mash (potato starch in deionized water) using a mortar and pestle and homogeneously distributed using a magnetic stirrer; the substance was administered as a single dose by gavage. After administration of the compound, the animals were observed for 14 days; at the end of the observation period, surviving animals were killed and an autopsy performed.
No death occurred and no symptoms were observed during the entire observation period. No impairment of body weight development was recorded. The animals at the end of the post-observation period were free of macroscopically visible changes.
Conclusion
LD50 (male and female) > 2000 mg/kg bw
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