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EC number: 232-266-0 | CAS number: 7803-65-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Experimental data from various test chemicals
- Justification for type of information:
- Data for the target chemical is summarized based on data from various test chemicals
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from publication
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- A Patch-Test was conducted on humans to determine the degree of contact sensitization caused by the test chemical.
- GLP compliance:
- not specified
- Type of study:
- patch test
- Justification for non-LLNA method:
- Not Specified
- Species:
- other: Human
- Strain:
- other: Not applicable
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data available
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: Urea
- Concentration / amount:
- No data available
- Day(s)/duration:
- 46 hours
- Adequacy of induction:
- not specified
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: urea
- Concentration / amount:
- No data available
- Day(s)/duration:
- 48 hours
- Adequacy of challenge:
- not specified
- No. of animals per dose:
- No data available
- Details on study design:
- No data available
- Challenge controls:
- No data available
- Reading:
- 1st reading
- Hours after challenge:
- 46
- Group:
- test chemical
- Dose level:
- No data available
- No. with + reactions:
- 0
- Clinical observations:
- The chemical did not cause skin sensitization.
- Remarks on result:
- no indication of skin sensitisation
- Interpretation of results:
- other: not sensitizing
- Conclusions:
- The test chemical did not induce contact senstization on humans when tested in a 46-h exposure human skin patch test. Hence the test chemical is considered to be not sensitizing to the skin of human subjects.
- Executive summary:
Patch-Test was conducted on humans to determine the degree of contact sensitization caused by the chemical. An aqueous solution of the test chemical (with urea) was negative when applied in a 46-h exposure human skin patch test. The test chemical did not induce contact senstization on humans when tested in a 46-h exposure human skin patch test. Hence the test chemical is considered to be not sensitizing to the skin of human subjects.
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from publication
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- The skin sensitization study of test chemical was studied in guinea pigs to determine the skin sensitization potential of test chemical.
- GLP compliance:
- not specified
- Type of study:
- other: Not Specified
- Justification for non-LLNA method:
- Not Specified
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data available
- Route:
- other: No data available
- Route:
- other: No data available
- No. of animals per dose:
- No data available
- Details on study design:
- No data available
- Challenge controls:
- No data available
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- No data available
- No. with + reactions:
- 0
- Clinical observations:
- The chemical did not cause skin sensitization in the guinea pigs.
- Remarks on result:
- no indication of skin sensitisation
- Interpretation of results:
- other: Not senstizing
- Conclusions:
- The test chemical was considered to be not sensitizing to the skin of guinea pig.
- Executive summary:
The skin sensitization study of test chemical was studied using guinea pigs to determine the skin sensitization potential of test chemical. When the test chemical was applied dermally to the skin of guinea pig, none of the treated guinea pigs showed the induction of skin sensitization. Hence the test chemical was considered to be not sensitizing to the skin of guinea pig.
Data source
Reference
- Reference Type:
- publication
- Title:
- WoE of skin sensitization study for CAS no 7803-65-8
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 019
- Bibliographic source:
- WoE report, Sustainabiliity Support Services (Europe) AB, 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- WoE for the target CAS is summarized based on data from various test chemicals
- GLP compliance:
- not specified
- Type of study:
- other: 2. Patch test; 3. No data
- Justification for non-LLNA method:
- Not Specified
Test material
- Reference substance name:
- Ammonium phosphinate
- EC Number:
- 232-266-0
- EC Name:
- Ammonium phosphinate
- Cas Number:
- 7803-65-8
- Molecular formula:
- H3N.H3O2P
- IUPAC Name:
- ammonium phosphinate
- Details on test material:
- - Name of test material : Ammonium phosphinate
- Molecular formula : H4NO2P
- Molecular weight : 83.0264 g/mol
- Smiles notation : [NH4+].[O-]P=O
- InChl : 1S/H3N.H3O2P/c;1-3-2/h1H3;3H2,(H,1,2)
- Substance type: Inorganic
- Physical state: Solid
Constituent 1
In vivo test system
Test animals
- Species:
- other: 2. Human; 3. Guinea pigs
- Strain:
- other: Not applicable
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data available
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: Urea
- Remarks:
- 2
- Concentration / amount:
- No data available
- Day(s)/duration:
- 46 hours
- Adequacy of induction:
- not specified
- Route:
- other: No data available / 3
Challengeopen allclose all
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: urea
- Remarks:
- 2
- Concentration / amount:
- No data available
- Day(s)/duration:
- 48 hours
- Adequacy of challenge:
- not specified
- Route:
- other: No data available / 3
- No. of animals per dose:
- No data available
- Details on study design:
- No data available
- Challenge controls:
- No data available
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 46
- Group:
- test chemical
- Dose level:
- No data available / 2
- No. with + reactions:
- 0
- Clinical observations:
- The chemical did not cause skin sensitization.
- Remarks on result:
- no indication of skin sensitisation
- Remarks:
- 2
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- No data available / 3
- No. with + reactions:
- 0
- Clinical observations:
- The chemical did not cause skin sensitization in the guinea pigs.
- Remarks on result:
- no indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- other: not sensitizing
- Conclusions:
- The test chemical did not induce contact senstization on humans and guinea pigs when tested in skin sensitization est. Hence the test chemical is considered to be not sensitizing to the skin.
- Executive summary:
Data available for the various test chemicals was reviewed to determine the skin sensitization study of the test chemical. The studies are as mentioned below:
Patch-Test was conducted on humans to determine the degree of contact sensitization caused by the chemical. An aqueous solution of the test chemical (with urea) was negative when applied in a 46-h exposure human skin patch test. The test chemical did not induce contact senstization on humans when tested in a 46-h exposure human skin patch test. Hence the test chemical is considered to be not sensitizing to the skin of human subjects.
In another study, the skin sensitization study of test chemical was studied using guinea pigs to determine the skin sensitization potential of test chemical. When the test chemical was applied dermally to the skin of guinea pig, none of the treated guinea pigs showed the induction of skin sensitization. Hence the test chemical was considered to be not sensitizing to the skin of guinea pig.
.
Based on the data available and applying trhe weight of evidence approach, the test chemical did not induce contact senstization on humans and guinea pigs when tested in skin sensitization test. Hence the test chemical is considered to be not sensitizing to the skin
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