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EC number: 209-667-4 | CAS number: 589-98-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Toxicity of a Homologous Series of Branched-Chain Primary Alcohols
- Author:
- R. A. SCALA & E. G. BURTIS
- Year:
- 1 973
- Bibliographic source:
- American Industrial Hygiene Association Journal, (1973), 34:11, 493-499
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- An ocular irritation study of chemical 2-ethylhexyl alcohol was conducted on six rabbits to assess its eye irritation potential.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-ethylhexan-1-ol
- EC Number:
- 203-234-3
- EC Name:
- 2-ethylhexan-1-ol
- Cas Number:
- 104-76-7
- Molecular formula:
- C8H18O
- IUPAC Name:
- 2 ethylhexan-1-ol
- Test material form:
- liquid
- Details on test material:
- - Name of test material: 2-Ethyl-1-hexanol
- IUPAC name: 1-Hexanol, 2-ethyl-
- Molecular formula: C8H18O
- Molecular weight: 130.2292 g//mol
- Substance type: Organic
- Physical State: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: 2-Ethyl-1-hexanol
- IUPAC name: 1-Hexanol, 2-ethyl-
- Molecular formula: C8H18O
- Molecular weight: 130.2292 g//mol
- Substance type: Organic
- Physical State: Liquid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or tissues and environmental conditions:
- no data available
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 ml of undiluted alcohol
- Duration of treatment / exposure:
- Treated eye was closed for 30 seconds
- Observation period (in vivo):
- 24, 72 hours and 7 days
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- Six
- Details on study design:
- TEST SITE
Area of exposure: conjunctival sac of left eye
% coverage: No data
Type of wrap if used: no wrap used
REMOVAL OF TEST SUBSTANCE
Washing (if done): no washing performed
Time after start of exposure: not applicable
SCORING SYSTEM: Grading scale is slight-moderate-marked and severe.
Signs of irritation exposure were graded and scored according to the method of Draize.
TOOL USED TO ASSESS SCORE: hand-slit lamp / biomicroscope / fluorescein: Initially and at termination the eyes were examined following instillation of 2 % sodium fluorescein solution to detect any corneal lesions if not otherwise visible.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 19
- Reversibility:
- not specified
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 20
- Reversibility:
- not specified
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Persistent widespread corneal opacity was observed
Any other information on results incl. tables
Acute Eye Irritation from Oxo Alcohols
Alcohol |
Irritation* |
Median score** |
||
24 hours |
72 hours |
7 days |
||
2-ethylhexyl |
Severe |
19 |
20 |
0 |
*-Grading Scale is: Slight-moderate-severe
**- Based on the scoring system of Draize
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The median scores were 19, 20 and 0 at 24 hours, 72 hours and day 7 respectively. Persistent widespread corneal opacity was observed till 7 days in the rabbits.
Hence, 2-ethylhexyl alcohol was considered to be severely irritating to rabbit eyes. - Executive summary:
An ocular irritation study of 2-ethylhexyl alcohol was conducted on six rabbits to assess its eye irritation potential.
A single application of 0.1 ml of undiluted alcohol was made into the conjunctival sac of the left eye of each of six rabbits. The untreated eye served as the control. The treated eye was closed for 30 seconds and eyes were not washed. Observations for irritancy and possible systemic toxicity were made at 1, 4, and 24 hours and at 2, 3, 4, and 7 days. Where positive effects persisted, observations were continued initially and at termination the eyes were examined following instillation of 2 % sodium fluorescein solution to detect any corneal lesions if not otherwise visible. Signs of irritation exposure were graded and scored according to the method of Draize.
Persistent widespread corneal opacity was observed till 7 days in the rabbits.
The median scores were 19, 20 and 0 at 24 hours, 72 hours and day 7 respectively.
Hence, 2-ethylhexyl alcohol was considered to be severely irritating to rabbit eyes.
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