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Diss Factsheets
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EC number: 203-715-8 | CAS number: 109-88-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study without detailed documentation.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Magnesium chloride
- EC Number:
- 232-094-6
- EC Name:
- Magnesium chloride
- Cas Number:
- 7786-30-3
- Molecular formula:
- Cl2Mg
- IUPAC Name:
- magnesium dichloride
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- B6C3F1
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: Oriental MF powdered diet and corn oil
- Duration of treatment / exposure:
- 13 weeks
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
0.3 %
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
0.6 %
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
1.25 %
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
2.5 %
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
5 %
Basis:
nominal in diet
- No. of animals per sex per dose:
- 10 mice per sex per dose.
- Control animals:
- yes, plain diet
Results and discussion
Effect levels
- Dose descriptor:
- LOAEL
- Effect level:
- 2.5 other: %
- Sex:
- male/female
- Basis for effect level:
- other: This was the minimum toxic dose tested.
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
No treatment related effects were noted at any dose levels for survival, clinical observation, hematology or blood biochemistry. The average body weights of both sexes fed the diet containing 5 % magnesium chloride were lower than those fed the control diet. Significant increases in the relative weights of some organs were observed in both sexes of the 2.5 and 5 % groups. However, no blood biochemical or histopathological changes were found. A significant decrease in the relative spleen weight was noted in the male 2.5 and 5 % groups. Organ weight changes were considered to be simply related to the lower body weight, since no hematological or histopathological alterations were seen. Renal cell vacuolation was found in high dose males (but not in females). This change might reflect reabsorption of magnesium, but as this alteration was not linked with change in any blood biochemical parameters indicating renal failure, its toxicological significance was considered to be minimal.
Applicant's summary and conclusion
- Conclusions:
- In conclusion, only high levels of magnesium chloride (2.5 and 5 %) exert any toxic effects and these are limited to minimal renal tubular changes in male mice. Therefore the toxic hazard of magnesium chloride is negligible.
- Executive summary:
Clinical signs and hematological or blood biochemistry parameters showed no treatment-related effects. Vacuolation of kidney tubular cells was apparent in males in high dose groups. This study demonstrated that a diet containing over 2.5 % magnesium chloride exerts toxic effects in mice. In conclusion, a level of 2.5 % in the diet is the minimal toxic dose.
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