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EC number: 603-450-1 | CAS number: 1310-39-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- transformation / dissolution of metals and inorganic metal compounds
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016-01-25 to 2016-03-23
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- the pH should be between 5.5 and 8.5 instead of 6 and 8, three instead of five replicates were tested twice insted of triple, the temperature differ more than 2 °C in the range of 20 - 25 °C.
- Qualifier:
- according to guideline
- Guideline:
- OECD Series on Testing and Assessment No. 29 (23-Jul-2001): Guidance document on transformation/dissolution of metals and metal compounds in aqueous media
- Deviations:
- yes
- Remarks:
- the pH should be between 5.5 and 8.5 instead of 6 and 8, three instead of five replicates were tested twice insted of triple, the temperature differ more than 2 °C in the range of 20 - 25 °C.
- Qualifier:
- according to guideline
- Guideline:
- other: EEC guideline SANCO/3029/99
- Version / remarks:
- rev. 4 dated 11/07/00
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed 2014-10-22
- Type of method:
- other: transformation / dissolution
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Element analysed:
- 56Fe, 47Ti, 27Al
- Loading of aqueous phase:
- 1 mg/L
- Incubation duration:
- 28 d
- Test conditions:
- pH 6; agitation at 100 rpm; room temperature
- Remarks on result:
- not determinable
- Remarks:
- lower than the method Limit of Detection (LOD = 0.5 µg/L for Fe, Ti and Al)
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Element analysed:
- 56 Fe, 47Ti, 27Al
- Loading of aqueous phase:
- 1 mg/L
- Incubation duration:
- 28 d
- Test conditions:
- pH 8; agitation at 100 rpm; room temperature
- Remarks on result:
- not determinable
- Remarks:
- lower than the method Limit of Detection (LOD = 0.5 µg/L for fe, Ti, Al)
- Details on results:
- The within-vessel variation and the between-vessel variation were less than 10% and less than 20 %, respectively, in accordance with OECD Series No. 29.
According to the SANCO/3029/99 rev. 4 guideline, the RSD are lower than 20 % for all tested media and fortification levels.
According to the SANCO/3029/99 rev. 4 guideline, the individual recovery values are in the range from 70 to 110 % with a mean between 80 to 100 % for all tested media and fortification levels. - Conclusions:
- The transformation/dissolution of pseudobrookite was determined according to OECD Series on Testing and Assessment No. 29 (ENV/JM/MONO(2001)9) and EEC guideline SANCO/3029/99 rev. 4 dated 11/07/00. A full transformation/dissolution test with a loading of 1 mg/L in two artificial media (pH 6 and pH 8) agitated at 100 rpm over 28 days at room temperature was conducted. The dissolved concentrations of iron, titanium and aluminium were lower than the LOD (0.5 µg/L) and therefore not determinable.
Reference
Linearity
The nominal range of Iron, Titanium and Aluminium concentrations, from 0.50 µg/L to 200.00 µg/L, was found to be linear (correlation coefficient > 0.99).
The instrumental limit of detection (I.D.L.) defined as the lowest calibration level, was 0.5 µg/L for Iron, Titanium and Aluminium.
The limit of quantification (L.O.Q.) of the method was fixed at 1 µg/L, defined as the lowest fortification level.
The limit of detection (L.O.D.) of the method, defined as 50% of the lowest fortification level, was 0.5 µg/L.
Iron, Titanium and Aluminium concentrations lower than the L.O.D. were classified as not detected (n.d.).
Repeatability (Precision) and Accuracy (Recovery)
Since the fortification levels for the recovery test were 1 µg/L and 10 µg/L, the linear calibration performed for recovery quantification ranged from 0.50 µg/L to 200.00 µg/L.
For precision, the SANCO/3029/99 rev. 4 guideline requires an RSD to be lower than 20 % for all tested media and fortification levels.
For accuracy, the SANCO/3029/99 rev. 4 guideline requires individual recovery values in the range from 70 to 110 % with a mean between 80 to 100 % for all tested media and fortification levels.
From the results of the accuracy test it can be concluded that there was not a matrix effect and contamination (e.g. by the filter procedure) did not occur during sample processing.
From data obtained, these criteria were fulfilled and therefore precision and accuracy of the analytical method is acceptable.
For each test medium an ICP-MS sequence with working standard solutions, Control, Spike Low, Spike High solution samples and Certified Reference Material samples was performed.
Mean recovery of fortified samples in two artificial media at pH 6 and pH 8
|
Artifical media pH 6 |
Artifical media pH 8 |
Fe spiked low (1 µg/L) |
94.91 % ± 0.64 % |
89.01 % ± 0.22 % |
Fe spiked high (10 µg/L) |
98.04 % ± 0.68 % |
91.64 % ± 1.29 % |
Ti spiked low (1 µg/L) |
89.02 % ± 1.54 % |
85.48 % ± 1.01 % |
Ti spiked high (10 µg/L) |
96.99 % ± 0.79 % |
93.85 % ± 1.27 % |
Al spiked low (1 µg/L) |
85.63 % ± 0.25 % |
84.54 % ± 0.63 % |
Al spiked high (10 µg/L) |
92.15 % ± 1.53 % |
92.46 % ± 0.54 % |
Temperature, pH and dissolved oxygen after in two artificial media at pH 6 and pH 8
Media |
Temperature |
pH |
Dissolved oxygen |
Artificial media pH 6 |
≥ 21.0 °C ≤ 25.1 °C |
≥ 5.936 ≤ 6.22 |
≥ 80.1 % ≤ 82.8 % |
Artificial media pH 8 |
≥ 20.9 °C ≤ 25.1 °C |
≥ 7.842 ≤ 8.070 |
≥ 80.1 % ≤ 82.4 % |
Description of key information
A full transformation/dissolution test with a loading of 1 mg/L in two artificial media (pH 6 and pH 8) agitated at 100 rpm over 28 days at room temperature was conducted. The dissolved concentrations of iron, titanium and aluminium were lower than the LOD (0.5 µg/L) and therefore not determinable.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.