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EC number: 604-144-0 | CAS number: 139525-77-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The determination was carried out by differential scanning calorimetry, using a procedure designed to be compatible with Method A.1 Melting/Freezing Temperature of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 102 of the OECD Guidelines for Testing of Chemicals, 27 July 1995 and Method 830.7200 of the OPPTS Guidelines, March 1998.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Principles of method if other than guideline:
- The temperature accuracy of the DSC was checked prior to testing with indium and zinc. These were within defined tolerances and the DSC was therefore considered acceptable for use.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
Test material
- Reference substance name:
- 604-144-0
- EC Number:
- 604-144-0
- Cas Number:
- 139525-77-2
- Molecular formula:
- C13H15NO.HCl
- IUPAC Name:
- 604-144-0
- Test material form:
- solid: particulate/powder
- Details on test material:
- White powder
Constituent 1
- Specific details on test material used for the study:
- Batch Number : 18113833
Aliquots of test item were placed in crucibles and were subjected to a thermal programs (see table below).
The appearance of the samples was recorded before and after the test, their weight change were recorded after the test.
Results and discussion
Melting / freezing pointopen allclose all
- Key result
- Melting / freezing pt.:
- ca. 216.16 °C
- Key result
- Melting / freezing pt.:
- ca. 216.04 °C
Any other information on results incl. tables
The thermograms and thermographic data for determinations 1 and 2 are shown in the following figures and in the following table.
Mean melting temperature: 216 ± 0.5 °C (489 ± 0.5 K)
Thermal Event |
Interpretation |
Determination 1 (Temperature) |
Determination 2 (Temperature) |
Endotherm extrapolated onset temperature | Melting Point | 216.16 °C (489.3 K) | 216.04 °C (489.2 K) |
Weight Loss | 7.9% | 10.9% |
The temperature program range selected was based on endotherm temperatures observed during preliminary evaluations carried out using a temperature program of ambient to 400 °C at 20 °C/min (see boiling temperature). Although discoloration of the test item residue was observed on completion of each determination at 250 °C, the thermograms showed the beginning of decomposition above the temperature of 230 °C, suggesting that the test item melted without significant decomposition.
Applicant's summary and conclusion
- Conclusions:
- The temperature program range selected was based on endotherm temperatures observed during preliminary evaluations carried out using a temperature program of ambient to 400 °C at 20 °C/min (see boiling temperature section 4.2). Although discoloration of the test item residue was observed on completion of each determination at 250 °C, the thermograms showed the beginning of decomposition above the temperature of 230 °C, suggesting that the test item melted without significant decomposition.
- Executive summary:
The melting point of the test Mephtamin HCL has been determined to be 216 ± 0.5 °C (489 ± 0.5 K).
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