1-Naphthaleneethanamine, 7-methoxy-, hydrochloride (1:1)

Melting point / freezing point

Administrative data

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

April 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

The determination was carried out by differential scanning calorimetry, using a procedure designed to be compatible with Method A.1 Melting/Freezing Temperature of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 102 of the OECD Guidelines for Testing of Chemicals, 27 July 1995 and Method 830.7200 of the OPPTS Guidelines, March 1998.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2016

Report date:

2016

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Principles of method if other than guideline:

The temperature accuracy of the DSC was checked prior to testing with indium and zinc. These were within defined tolerances and the DSC was therefore considered acceptable for use.

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Test material

Test material information

Constituent 1

Reference substance name:

604-144-0

EC Number:

604-144-0

Cas Number:

139525-77-2

Molecular formula:

C13H15NO.HCl

IUPAC Name:

604-144-0

Test material form:

solid: particulate/powder

Details on test material:

White powder

Specific details on test material used for the study:

Batch Number : 18113833
Aliquots of test item were placed in crucibles and were subjected to a thermal programs (see table below).
The appearance of the samples was recorded before and after the test, their weight change were recorded after the test.

Results and discussion

Melting / freezing point

Melting / freezing point 1

Key result

Melting / freezing pt.:

ca. 216.16 °C

Melting / freezing point 2

Key result

Melting / freezing pt.:

ca. 216.04 °C

Any other information on results incl. tables

The thermograms and thermographic data for determinations 1 and 2 are shown in the following figures and in the following table.

Mean melting temperature: 216 ± 0.5 °C (489 ± 0.5 K)

Thermal Event	Interpretation	Determination 1 (Temperature)	Determination 2 (Temperature)
Endotherm extrapolated onset temperature	Melting Point	216.16 °C (489.3 K)	216.04  °C (489.2 K)
Weight Loss		7.9%	10.9%

The temperature program range selected was based on endotherm temperatures observed during preliminary evaluations carried out using a temperature program of ambient to 400 °C at 20 °C/min (see boiling temperature). Although discoloration of the test item residue was observed on completion of each determination at 250 °C, the thermograms showed the beginning of decomposition above the temperature of 230 °C, suggesting that the test item melted without significant decomposition.

Applicant's summary and conclusion

Conclusions:

The temperature program range selected was based on endotherm temperatures observed during preliminary evaluations carried out using a temperature program of ambient to 400 °C at 20 °C/min (see boiling temperature section 4.2). Although discoloration of the test item residue was observed on completion of each determination at 250 °C, the thermograms showed the beginning of decomposition above the temperature of 230 °C, suggesting that the test item melted without significant decomposition.

Executive summary:

The melting point of the test Mephtamin HCL has been determined to be 216 ± 0.5 °C (489 ± 0.5 K).