3-(dimethoxymethylsilyl)propanethiol

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

1990

Report date:

1990

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Deviations:

not specified

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

3-trimethoxysilylpropane-1-thiol

EC Number:

224-588-5

EC Name:

3-trimethoxysilylpropane-1-thiol

Cas Number:

4420-74-0

IUPAC Name:

3-(trimethoxysilyl)propane-1-thiol

Details on test material:

- Name of test material (as cited in study report): Organofunctional Silane Y-9616 (gamma-mercaptopropyltrimethoxysilane)
- Substance type: Organosilane
- Physical state: Liquid
- Stability under test conditions:
- Storage condition of test material: No data

Test animals

Species:

rabbit

Strain:

New Zealand White

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: No data
- Housing: No data
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: No data


ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): no data

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

not required

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml

Duration of treatment / exposure:

Four hours

Observation period:

14 days

Number of animals:

Six

Details on study design:

TEST SITE
- Area of exposure: No data
- % coverage: No data
- Type of wrap if used: occlusive


REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: four hours


SCORING SYSTEM: Draize

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

mean

Time point:

24/48/72 h

Score:

0

Max. score:

4

Remarks on result:

no indication of irritation

Results 2

Irritation parameter:

edema score

Basis:

mean

Time point:

24/48/72 h

Score:

0

Max. score:

4

Remarks on result:

no indication of irritation

Irritant / corrosive response data:

No erythema or oedema was observed in any animal at any time point.

Other effects:

No other effects reported.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

In a detailed summary of a skin irritation study (reliability score 2; not to GLP), gamma-mercaptopropyltrimethoxysilane was not irritating to the skin of New Zealand white rabbits.

Executive summary:

Undiluted gamma-mercaptopropyltrimethoxysilane (0.5 ml) was applied to the intact (shaved) skin of six New Zealand white rabbits for four hours under an occlusive dressing. The dressings were then removed, the skin washed and the skin reactions observed for up to 14 days. None of the rabbits had any signs of skin irritation, and no other clinical signs of toxicity were observed. It was therefore concluded by the study authors that the test substance was not irritating to the skin.