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EC number: 249-616-3 | CAS number: 29420-49-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate
- EC Number:
- 249-616-3
- EC Name:
- Potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate
- Cas Number:
- 29420-49-3
- Molecular formula:
- C4HF9O3S.K
- IUPAC Name:
- potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Lot number 2
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature, protected from light
FORM AS APPLIED IN THE TEST (if different from that of starting material): The test material was moistened with 1% carboxymethylcellulose (CMC) in deionized water.
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Inc.
- Females (if applicable) nulliparous and non-pregnant: Yes
- Age at study initiation: Six to eight weeks
- Weight at study initiation: Males 240.0 +/- 5.8g, females 167.6 +/- 2.1g
- Fasting period before study: Not fasted
- Housing: The animals will be individually housed in stainless steel cages. The cages conform to standards-set forth in the Guide for the Care and Use
of Laboratoy Animals, National Academy Press, Washington, D.C.,1996.
- Diet (e.g. ad libitum): Teklad Certified Rodent Diet #8728 will be provided ad libitum. This diet is routinely analyzed by the manufacturer for nutritional components and environmental contaminants. Results of the manufacturer's analyses are on file at Primedica Redfield.
- Water (e.g. ad libitum): Filtered tap water will be provided ad libitum. Samples of the water are analyzed for total dissoNed solids, hardness, specified microbiological content, and for environmental contaminants. Results of these analyses aare on file at Primedica Redfield.
- Acclimation period: Animals will be acclimated for a minimum of seven days prior to the study start. During the acclimation period, the animals were habituated to collars used during the study.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18-26C
- Humidity (%): 30-70%
- Air changes (per hr): Ten or greater changes per hour
- Photoperiod (hrs dark / hrs light): 12:12 hour light:dark cycle
IN-LIFE DATES: From: 27 July 2000 To: 11 August 2000
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Dorsal area of the trunk
- % coverage: Approximately 10% of the body surface area
- Type of wrap if used: Porous gauze dressing with non-irritating tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Test material removed with warm water and gauze
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg wetted to a paste with medium viscosity carboxymethylcellulose
- For solids, paste formed: Yes
VEHICLE
- Lot/batch no. (if required): 69H0028 - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5/sex/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Pretest and on study day 1, 8, and 15
- Necropsy of survivors performed: Yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Treatment with T-7485 produced no test material-related mortalities, but there was one procedural death that resulted in the replacement of a male rat.
- Clinical signs:
- other: Clinical observations included red material around the eyes, nose, and mouth. These observations were not present after Study Day 2 and were not considered test material-related.
- Gross pathology:
- There were no adverse gross findings recorded for either male or female rats treated with 2000 mg/kg T-7485 with the exception of one male (this male was replaced) which died due to procedural complications.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- No mortality occurred and no clinical signs of toxicity were observed.
- Conclusions:
- Based on the results of the study, the rat dermal LD50 of T-7485 is >2000 mg/kg.
- Executive summary:
The acute dermal lethality of T-7485 was determined in rats. Sprague-Dawley rats (5/sex/dose) received 2000 mg/kg T-7485 mixed with enough carboxymethylcellulose in water to for form a paste to the dorsal area of the trunk (approximately 10% of the body surface area). Observations for mortality and morbundity (recorded twice daily), body weights (pretest and day 1, 8, and 15), clinical signs (predose and approximately hourly for four hours postdose on study day 1 and once daily thereafter for at least 14 days), and macroscopic examination (at necropsy). At 2000 mg/kg all animals survived; one male rat died due to procedural complications and was replaced. Clinical observations included red material around the eyes, nose and mouth, however, these were not present after day 2 of the study and were not considered to be related to test material exposure. No adverse effects on body weights or body weight changes were seen. When compared to Study Day 1, Study Days 8 and 15 male mean body weights were increased 17% and 40%, respectively. Likewise, female mean body weights were increased 8% and 19%, respectively. On Study Days 1 through 15, male mean body weight change was increased 96.6g while bodyweight change in the females was increased 31.6g. No adverse gross findings were recorded for either sex with the exception of one male rat (previously stated) which died due to procedural complications. Based on the results of the study, the rat dermal LD50 of T-7485 is >2000 mg/kg.
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