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Diss Factsheets
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EC number: 266-369-7 | CAS number: 66469-15-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Justification for type of information:
- The presented study was conducted with isooctadecanoic acid. The read across source substance is considered a structural analogue with regard to environmental fate and effects on aquatic organisms taking into account the physico-chemical properties (surface active properties, logKow, water solubility) and the chemical structure of the test item (potassium soap of isooctadecanoic acid) and therefore the results of the source substance are considered relevant for risk assessment. See read across document for further details.
- Qualifier:
- according to guideline
- Guideline:
- other: Bewertung wassergefährdender Stoffe, Bestimmung der akuten Fischtoxozität, Ad-hoc Arbeitsgruppe 1, LTwS, Nr. 10, Sept 1979
- Deviations:
- yes
- Remarks:
- Total exposure duration 48 h instead of 96h exposure of a guideline OECD 203 study. Use of Tween 80 as dispersing agent
- Principles of method if other than guideline:
- - Total exposure duration 48 h instead of 96h exposure of a guideline OECD 203 study.
- Use of Tween 80 as dispersing agent - GLP compliance:
- yes
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Prisorine 3505, Isostearic acid
- Physical state: liquid
- Analytical purity: +/- 100 %
- Lot/batch No.: 80011
- Storage condition of test material: at ambient temperature in the dark - Analytical monitoring:
- no
- Vehicle:
- yes
- Details on test solutions:
- Preparation and application of test solution(especially for difficult test substances):
- Test substance was homogenuously dispersed using Tween 80 (10 mg/L)
- Controls: yes
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): Tween 80 - Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- Test organism
- Source: Zodiac, Wageningen, the Netherlands
- Length at study initiation (length definition, mean, range and SD): 2-4 cm
- Feeding during test: no
Acclimatization
- Type and amount of food: Artemia and Trouvite 00
- Feeding frequency: at least once a day
- Health during acclimation (any mortality observed): mortality during seven days prior to start of test was less than 1% - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 11.7°DH (DSW: Dutch Standard Water)
- Test temperature:
- 20 - 21°C
- pH:
- 0 - 56 mg/L: 7.8 - 8.4
100 mg/L: 7.0 - 7.6 - Dissolved oxygen:
- 8.1 - 8.6 mg/L
- Nominal and measured concentrations:
- Nominal concentrations: 0, 1, 1.8, 3.2, 5.6, 10, 18, 32, 56, 100 mg/L
No actual concentrations measured. - Details on test conditions:
- Test system/Test vessel
- Material, size, headspace, fill volume: 10 L glass vessels
- Aeration: yes
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): 1
Test medium / Water parameter
- Source/preparation of dilution water: Dutch Standard Water (DSW):Ca2+: 54.5 mg/LMg2+: 17.8 mg/LNa+: 27.4 mg/LK+: 7.8 mg/LCl-: 96.3 mg/LHCO3-: 84.8 mg/LSO42-: 70.2 mg/L
Effect parameters measured (with observation intervals if applicable): mortality, after 2-3h, 24h, 48h
Test concentrations
- Range finding study - Test concentrations: 0.01 to 1000 mg/L (factor 10)
- Results used to determine the conditions for the definitive study: yes - Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 29.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% CL: 24.3 - 39.2 mg/L
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 13.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% CL: 10.9 - 16.5 mg/L
- Duration:
- 48 h
- Dose descriptor:
- LC0
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- mortality (fish)
- Duration:
- 48 h
- Dose descriptor:
- LC100
- Effect conc.:
- 32 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 5.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: After 48 hours alive fish at 10 mg/L showed a decrease in swimming ability.
- Mortality of control: none
- Effect concentrations exceeding solubility of substance in test medium: yes, but use of solubiliser Tween 80. - Sublethal observations / clinical signs:
This study determined a LC50 for the test substance of 13.4 mg/L after 48 hours. Thus it can be expected that the LC50 after 96 hours will be lower. The LC50 exceeds the water solubility of the test substance. The homogeous dispersion of the test substance in water could only be reached using the solubiliser Tween 80.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The LC50 for the test substance is 13.4 mg/L after 48 hours. The LC50 exceeds the water solubility of the test substance. The homogeous dispersion of the test substance in water could only be reached using the solubiliser Tween 80.
- Executive summary:
The LC50 for the test substance is 13.4 mg/L after 48 hours. The LC50 exceeds the water solubility of the test substance. The homogeous dispersion of the test substance in water could only be reached using the solubiliser Tween 80.
Reference
Description of key information
The LC50 for the test substance is 13.4 mg/L after 48 hours. The LC50 exceeds the water solubility of the test substance. The homogeous dispersion of the test substance in water could only be reached using the solubiliser Tween 80.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 13.4 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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