Registration Dossier
Registration Dossier
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EC number: 616-749-7 | CAS number: 79869-59-3
Endpoint summary
Administrative data
Description of key information
LD50 oral, rat > 10000 mg/kg
LD50 i.p., mice > 6810 mg/kg
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 10 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 4 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In an oral toxicity study comparable to OECD guideline 401, Sprague-Dawley rats (5/sex/dose) were administered the test substance at a single dose of 10000 mg/kg bw by gavage followed by a 14-day observation period. None of the animals died during the exposure period. Besides substance residues in the abdomen no abnormal findings were made at necropsy. The LD50 was > 10,000 mg/kg bw.
Regarding inhalation, only unreliable data is available for the test article. An inhalation risk test which demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components, was performed with the test article. The nominal concentration is calculated as quotient of the amount of the test substance weight loss during exposure. Two groups of rats (6/sex/group) were exposed sequentially to the dusts for 8 h. None of the animals died during the exposure period and no abnormal clinical signs were reported. Body weights and gross pathology were normal. Average concentration of the test article in the atmosphere was determined to be 4.78 mg/l. Since this test design is insufficient for non-volatile substances, this test is only taken into account as supporting information.
Justification for classification or non-classification
Based on the available information the test substance does not need to be classified for acute oral toxicity in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
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