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EC number: 202-182-9 | CAS number: 92-72-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Appearance / physical state / colour
Administrative data
- Endpoint:
- appearance / physical state / colour
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: observation made during recent daphnia testing
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016/07/26-2017/12/11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 2004
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- TREATMENT OF TEST MATERIAL PRIOR TO TESTING
-The test item has a low water solubility, therefore, the test item was applied as water accommodated fraction (WAF).
The WAF was used as application solution (~ 50 mL of the prepared solution was transferred to each test vessel). - Analytical monitoring:
- yes
- Details on sampling:
- - Sampling method: analytical samples taken at 0 hours (initial value) and 48 hours from aged test solutions were analysed from control and test item loading rate. Analyses on sampling point 24h were made but not reported on the Result Tables.
- Fortified samples: a stock solution (2000 mg/L, purity not considered) was prepared in acetonitrile. A dilution (10 mg/L) was prepared in acetonitrile. The stock solution and the 10 mg/L dilution was used for fortification of 0.03 mg/L and 60 mg/L recovery samples.
- Sample storage (before test): stored deep-frozen until analysis - Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain/clone: straus, clone 5
- Feeding during test: no feeding during test
- Feeding of culture (before test): three times a week with single cell green algae
- Main test: freshly hatched daphnids less than 24 hours old were used - Test type:
- static
- Water media type:
- other: Elendt M4
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 232 mg/L CaCO3
- Test temperature:
- 20.0 – 21.8 °C
- pH:
- 7.61 – 7.91
- Dissolved oxygen:
- ≥ 8.4 mg/L
- Nominal and measured concentrations:
- Nominal concentration: 100 mg/L and a control
Measured concentration (geometric mean based): 4.31 mg/L and not determined for the control - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass vessel
- Type: covered with a glass plate (to reduce evaporation)
- Material, size, headspace, fill volume: 100 mL capacity filled with 50mL of test solution
- No. of organisms: 20 daphnids per treatment group (4 replicates of 5 animals each)
- No. of treatment groups: 2 (1 dose rate of the test item and a control)
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Elendt M4
- Culture medium different from test medium: same as Elendt M4
OTHER TEST CONDITIONS
- Exposure to light: none
EFFECT PARAMETERS MEASURED: Immobilisation
RANGE-FINDING STUDY
- Test concentrations: control, 100, 10, 1 and 0.1 mg/L
- Sampling points : after 24h and 48h of exposure
- Results used to determine the conditions for the definitive study:
-After 24 hours of exposure no immobilisation above the allowed control immobilisation was observed in the control and up to and including 100 mg/L.
-After 48 hours of exposure no immobilisation was observed in the control and up to and including 10.0 mg/L. 15 % immobilisation was observed at the highest test item loading rate of 100 mg/L. - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate, tested at 1.00 and 2.00 mg/L with 20 test organisms per test concentration, at around the same time period as the study
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 4.31 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 4.31 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Results with reference substance (positive control):
- - Results with reference substance valid? yes
- Test concencentrations: 1 and 2 mg/L (20 organisms per test concentration)
- Relevant effect levels: EC50 (24h) is below 1 mg/L. The results are in accordance with the requirements of the OECD guideline 202. - Validity criteria fulfilled:
- yes
- Conclusions:
- The 48-hour EC50 for Daphnia magna is > 4.31 mg/L (measured, geom. mean).
- Executive summary:
The short-term toxicity to Daphnia magna was determined according to OECD 202 guideline with no deviations. The study was conducted under static conditions, and it was a limit test. The daphnids were exposed over a period of 48 hours to a nominal concentration of 100 mg/L and a control. The measured concentration is 4.31 mg/L and for the control it was not determined.
The validity criteria were fulfilled.
The EC50 value was determined to be > 4.31 mg/L (measured, geom. mean).
Summary of biological results:
a) Results of the test, 24h values
Nominal test item loading rate [mg/L] |
|||
Control |
100 |
||
immobilised daphnids after 24 h |
|||
Group 1 |
0 |
0 |
|
Group 2 |
0 |
0 |
|
Group 3 |
0 |
0 |
|
Group 4 |
0 |
0 |
|
Σ |
0 |
0 |
|
% |
0 |
0 |
b) Results of the test, 48h values
Nominal item loading rate [mg/L] |
|||
Control |
100 |
||
immobilised daphnids after 48 h |
|||
Group 1 |
0 |
0 |
|
Group 2 |
0 |
0 |
|
Group 3 |
0 |
0 |
|
Group 4 |
0 |
0 |
|
Σ |
0 |
0 |
|
% |
0 |
0 |
Determined concentration of test substance:
Test item loading rate |
Test item |
Sampling |
Test item found |
Test item concentration |
||
nominal [mg/L] |
Nominal |
[h] |
[mg/L] |
% of nominal |
actual [mg/L] |
|
Control |
0 |
0 fresh |
n.d. |
- |
- |
|
24 aged |
n.d. |
- |
||||
48 aged |
n.d. |
- |
||||
100 |
100 |
0 fresh |
33.2 |
33 |
4.31 |
|
24 aged |
0.668 |
0.668 |
||||
48 aged |
0.456 |
0.456 |
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- no guideline followed, the results are obtained from observations made during a recent study on Algae testing of the substance.
- GLP compliance:
- no
Test material
- Reference substance name:
- 5'-chloro-3-hydroxy-2',4'-dimethoxy-2-naphthanilide
- EC Number:
- 202-182-9
- EC Name:
- 5'-chloro-3-hydroxy-2',4'-dimethoxy-2-naphthanilide
- Cas Number:
- 92-72-8
- Molecular formula:
- C19H16ClNO4
- IUPAC Name:
- 5'-chloro-3-hydroxy-2',4'-dimethoxy-2-naphthanilide
- Test material form:
- solid
- Details on test material:
- - Batch: 16021485
- Purity: 95.9%
- Colour: solid/greyish
- Expiry date: 2017-10-21
- Storage conditions: ambient (5-30 °C), dark, dry
Constituent 1
Results and discussion
- Physical state at 20°C and 1013 hPa:
- solid
Form / colour / odour
- Key result
- Form:
- solid
- Colour:
- greyish
- Substance type:
- organic
Applicant's summary and conclusion
- Conclusions:
- The test substance is a greyish solid product.
- Executive summary:
The results are obtained from observations made during a recent study on Algae testing of the substance
The substance is a greyish solid product.
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