Registration Dossier
Registration Dossier
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EC number: 701-203-3 | CAS number: -
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Accepted calculation method
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
- Principles of method if other than guideline:
- Calculation of dermal absorption based on Dermwin v2.02 (modified considering the Fick´s first law)
- GLP compliance:
- no
Test material
- Reference substance name:
- C18' (3EO) FA component of Sorbitan monooleate, ethoxylated
- IUPAC Name:
- C18' (3EO) FA component of Sorbitan monooleate, ethoxylated
- Details on test material:
- - Name of test material (as cited in study report): Sorbitan monooleate, ethoxylated, (3EO constituent)
- Molecular formula (if other than submission substance): C30 H56 O9
- Molecular weight (if other than submission substance): 560.8 g/mol
- Smiles notation: OC(COCCOCCOCCOC(=O)CCCCCCCC=CCCCCCCCC)C1OCC(O)C1O
- Water solubility: 30 - 100 mg/L
- log Pow: 5.06
Constituent 1
Test animals
- Species:
- other: not applicable
- Strain:
- other: not applicable
Administration / exposure
- Type of coverage:
- other: not applicable
- Vehicle:
- other: not applicable
- Duration of exposure:
- not applicable
- Doses:
- not applicable
- No. of animals per group:
- not applicable
Results and discussion
- Conversion factor human vs. animal skin:
- not applicable
Any other information on results incl. tables
Table 1: Dermal absorption potential of C18' 3EO FA component of Sorbitan monooleate, ethoxylated
|
MW (g/mol) |
Log Pow |
Water solubility (mg/L) |
Flux (µg/cm2/h) |
Dermal absorption (%) |
Dermwin v2.02 |
560.8 |
5.06 |
- |
9.16 E-4 |
low |
Dermwin v2.02 (modified considering the Fick´s first law) |
560.8 |
5.06 |
30 |
0.075 |
low (10%) |
Dermwin v2.02 (modified considering the Fick´s first law) |
560.8 |
5.06 |
100 |
0.251 |
medium low (20%) |
Applicant's summary and conclusion
- Conclusions:
- A low to moderate dermal absoprtion potential is estimated for Sorbitan monooleate with an ethoxylation degree of 3 EO resulting in a dermal absoprtion potential of not more than 20%.
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