Registration Dossier
Registration Dossier
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EC number: 251-780-6 | CAS number: 33996-33-7
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09/2017 to 2017-12-20
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995-07-27
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- May 2008
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- March 1998
- GLP compliance:
- no
- Type of method:
- flask method
Test material
- Reference substance name:
- Oxaceprol
- EC Number:
- 251-780-6
- EC Name:
- Oxaceprol
- Cas Number:
- 33996-33-7
- Molecular formula:
- C7H11NO4
- IUPAC Name:
- 1-acetyl-4-hydroxy-L-proline
- Test material form:
- solid: crystalline
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Batch 6716-16E
- Expiration date of the lot/batch: Retest date: 2018-10-23
- Purity test date: 2016-11-17
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: 20 °C +/- 5°C, in the desiccator in the dark
- Stability under test conditions: stable
- Solubility and stability of the test substance in the solvent/vehicle: soluble in water
Results and discussion
Water solubility
- Key result
- Water solubility:
- 381 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 20 °C
- pH:
- ca. 1.8
- Details on results:
- The results showed no tendency to increase and met all validity criteria, therefore the study is considered to be valid.
Applicant's summary and conclusion
- Conclusions:
- Corresponding to the analyses the water solubility of oxaceprol was determined to be 381 g/L at 20 °C.
The substance is highly soluble in water. - Executive summary:
The purpose of this guideline study was to evaluate the solubility of the test item in water which is specified by the saturation mass concentration of oxaceprol in water at a specified temperature.
The water solubility was determined using the shake flask method. The results showed no tendency to increase, therefore the study is considered to be valid.
Corresponding to the analyses the water solubility was determined to be 381 g/L at 20 °C.
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