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Diss Factsheets
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EC number: 234-746-5 | CAS number: 12030-88-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- screening for reproductive / developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- The spermicidal activity of hydrogen peroxide in vitro and in vivo
- Author:
- Wales RG
- Year:
- 1 959
- Bibliographic source:
- J Endocrin. 18: 236-244
Materials and methods
- Principles of method if other than guideline:
- Male reproductive toxicity study
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- Hydrogen peroxide
- EC Number:
- 231-765-0
- EC Name:
- Hydrogen peroxide
- Cas Number:
- 7722-84-1
- Molecular formula:
- H2O2
- IUPAC Name:
- Hydrogen peroxide
- Test material form:
- liquid
- Remarks:
- colourless
Constituent 1
- Specific details on test material used for the study:
- Purity: 30%
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: drinking water
- Duration of treatment / exposure:
- Exposure period: 7, 21 or 28 days
Premating exposure period (males): 7, 21 or 28 days - Frequency of treatment:
- Daily
- Details on study schedule:
- Exposure period: 7, 21 or 28 days
Premating exposure period (males): 7, 21 or 28 days
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0 other: %
- Remarks:
- in drinking water
- Dose / conc.:
- 0.33 other: %
- Remarks:
- in drinking water
- Dose / conc.:
- 1 other: %
- Remarks:
- in drinking water
- Dose / conc.:
- 3 other: %
- Remarks:
- in drinking water
- No. of animals per sex per dose:
- 12 males per dose
- Control animals:
- no
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Key result
- Dose descriptor:
- LOAEL
- Effect level:
- 0.33 other: %
- Based on:
- test mat. (dissolved fraction)
- Sex:
- male
- Basis for effect level:
- other: no treatment-related adverse effects except body weight gain
Results: F1 generation
Effect levels (F1)
- Key result
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- 3 other: %
- Based on:
- test mat. (dissolved fraction)
- Sex:
- male/female
- Basis for effect level:
- other: no treatment-related adverse effect
Overall reproductive toxicity
- Key result
- Reproductive effects observed:
- no
Applicant's summary and conclusion
- Conclusions:
- Under the study conditions, the substance had no significant effects on the reproductive capacity of male mice.
- Executive summary:
A study was conducted to determine the potential reprotoxicity of the substance. Male mice were administered the substance in drinking water at 0, 0.33, 1 and 3% for 7, 21 or 28 days before the mating period and then mated with normal females. The test substance treatment continued through the mating period. All female mice mated to treated males became pregnant within a few days and in each case healthy pups were born in litters of normal size. Pregnant mice that continued to consume 1% test substance in water until near term showed some delays in parturition compared to dams consuming untreated tap water, although the effect was small and inconsistent. The concentration, morphology and motility of the mouse spermatozoa after 3 weeks of treatment appeared normal. Under the study conditions, the substance had no significant effects on the reproductive capacity of male mice (Wales, 1959).
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