Registration Dossier
Registration Dossier
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EC number: 218-427-8 | CAS number: 2150-46-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in chemico
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- secondary source
- Title:
- OECD QSAR Toolbox v3.4
- Author:
- Anonymous
- Year:
- 2 017
- Bibliographic source:
- Safety & Environmental Assurance Centre, Unilever; International QSAR Foundation; The University of Tennessee
Materials and methods
- Principles of method if other than guideline:
- In-chemico assay for depletion of glutathione by coincubation with the test substance
- GLP compliance:
- not specified
- Type of study:
- direct peptide reactivity assay (DPRA)
Test material
- Reference substance name:
- Methyl 2,5-dihydroxybenzoate
- EC Number:
- 218-427-8
- EC Name:
- Methyl 2,5-dihydroxybenzoate
- Cas Number:
- 2150-46-1
- Molecular formula:
- C8H8O4
- IUPAC Name:
- methyl 2,5-dihydroxybenzoate
- Test material form:
- solid
Constituent 1
In chemico test system
- Details on the study design:
- None provided in the OECD Toolbox
Results and discussion
In vitro / in chemico
Results
- Remarks on result:
- positive indication of skin sensitisation
- Remarks:
- The substance was found to bind to glutathione.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
