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Diss Factsheets
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EC number: 283-381-8 | CAS number: 84604-96-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: assessment of physchem/ potential metabolic pathway
- Adequacy of study:
- key study
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Chemical structure of Zinc diisonoyl dithiocarbamate has main functional group associated with dithiocarbamates, structural functional groups include a Zinc ion with two diisononylamine dithiocarbamate ligands and exists in a divalent and tetravalent form
Relevant physicochemical properties :
)Molecular weight : 745g/mol or Da
Physical form : free flowing powder with mean aerodynamic diameter of 25µm (D50)
Vapour pressure : 8.5 X 10 -4 Pa at 25°C Low vapour pressure
Water solubility : 0.6 mg/l (poorly water soluble)
LogKow : >6.5 Hplc method
Hydrolysis TBD- testing underway
pH 9 ( 10% aq solution- distilled water)
pKa 3.4 ( relaible QSAR)
Absorption
pKa 3.4 – therefore Arbestb Z is largely unionised in stomach and ionised in intestines. We would therefore expect absorption of parent to occur in stomach & minimal parent absorption in intestine
Main routes are inhalation of dust, but dermal absorption is unlikely due to high molecular weight, greater than 500 Da
Absorption is evident with haemtological effects observed in repeat dose studies
Metabolism
Arbestab Z is likely to be metabolised in liver into dialkyldithiocarbamic acid or as a S-glucuronide conjugate with further metabolism to dialkylamine and carbon disulphide as most dithiocarbamates
Distribution
general absorbed dithiocarbamates can be found in following organs, liver, kidneys and thyroid gland, but accumulation of these compounds does not take place because of rapid metabolism.
Elimination
The biotransformation of dithiocarbamates in phase two conjugation with polar/hydrophillic glucuronide results in principle excretion via kidneys. - Executive summary:
Physchemical properties show the test item will undergo rapid metabolism
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