Registration Dossier
Registration Dossier
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EC number: 204-516-9 | CAS number: 122-03-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1972
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Open Epicutaneous (In Vivo) Study
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-isopropylbenzaldehyde
- EC Number:
- 204-516-9
- EC Name:
- 4-isopropylbenzaldehyde
- Cas Number:
- 122-03-2
- Molecular formula:
- C10H12O
- IUPAC Name:
- 4-(propan-2-yl)benzaldehyde
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
Test system
- Type of coverage:
- open
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- All substances were applied undiluted as well as dissolved in acetone, ethanol or diethylphthalate etc. at concentrations of 30, 10, 3, 1, 0.3, 0.1 and 0.03% in order to establish a dose response curve which would permit the determination of the minimal irritating and maximal tolerated concentrations on an "all or none" basis.
- Duration of treatment / exposure:
- 21 daily applications
- Number of animals:
- 6-8 animals per concentration
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: After single application
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Non-Irritant.
- Executive summary:
After a single application at 100%, only slight irritation was observed. No irritation was observed at 30%.
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