Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-660-8 | CAS number: 2492-26-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable, well-documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
- Principles of method if other than guideline:
- in vivo skin irritation study
- GLP compliance:
- yes
Test material
- Reference substance name:
- Sodium benzothiazol-2-yl sulphide
- EC Number:
- 219-660-8
- EC Name:
- Sodium benzothiazol-2-yl sulphide
- Cas Number:
- 2492-26-4
- Molecular formula:
- C7H4NS2.Na
- IUPAC Name:
- sodium 2-sulfanylidene-2,3-dihydro-1,3-benzothiazol-3-ide
- Details on test material:
- sodium MBT, Lot.: 7E090-FP 8085-011-31, 45% solution, pH>12
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: intact skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 7 days
- Number of animals:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 8
- Max. score:
- 8
- Reversibility:
- not reversible
- Remarks on result:
- other: corrosive, 7 days (injury in depth)
- Other effects:
- corrosive after 7 days (cratering - injury in depth)
Any other information on results incl. tables
An erythema score of 4 and an edema score of 4 was found 1h, 24h, 48h and 72h in all rabbits after patch removal. After 168 hours reading/scoring was judged as corrosive with cratering and injury in depth.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
- Executive summary:
Six New Zealand rabbits were applied 0.5 ml of undiluted sodium-mercaptobenzothiazole on the intact skin under semi-occlusive conditions for 4 hours. Skin reactions (erythema and edema) were scored according to Draize 1h, 24 h, 48h, 72 h and 168 h following patch removal.
An erythema score of 4 and an edema score of 4 was found 1h, 24h, 48h and 72h in all rabbits after patch removal. After 168 hours reading/scoring was judged as corrosive with cratering and injury in depth.
Therefor a classification as corrosive to skin (R34 causes burns) according to the classification criteria 67/548/EWG and regulation no. 1272/2008 (GHS) (skin corrosive category 1B, H 314: causes severe skin burns and eye damage) is justified as worst-case consideration because a differentiation between Skin Corrr.1C and Skin Corr.1B is not possible on the basis of the available data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.