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EC number: 617-879-7 | CAS number: 865536-03-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- bis(11-methyldodecyl) ((((1,3-phenylenebis(methylene)bis(azanediyl))bis(carbonyl) bis(azanediyl))bis(4-methyl-3,1-phenylene) dicarbamate
- Cas Number:
- 865536-03-4
- Molecular formula:
- C52H80N6O6
- IUPAC Name:
- bis(11-methyldodecyl) ((((1,3-phenylenebis(methylene)bis(azanediyl))bis(carbonyl) bis(azanediyl))bis(4-methyl-3,1-phenylene) dicarbamate
- Reference substance name:
- bis(11-methyldodecyl)(4-methyl-1,3-phenylene)dicarbamate
- Molecular formula:
- C35H62N2O4
- IUPAC Name:
- bis(11-methyldodecyl)(4-methyl-1,3-phenylene)dicarbamate
- Reference substance name:
- 11-methyldodecyl (3-(3-(3-(aminomethyl)benzyl)ureido)-4-methylphenyl)carbamate
- Molecular formula:
- C30H46N4O3
- IUPAC Name:
- 11-methyldodecyl (3-(3-(3-(aminomethyl)benzyl)ureido)-4-methylphenyl)carbamate
- Reference substance name:
- 1,1'-(4-methyl-1,3-phenylene)bis(3-(3-(aminomethyl)benzyl)urea)
- Molecular formula:
- C25H30N6O2
- IUPAC Name:
- 1,1'-(4-methyl-1,3-phenylene)bis(3-(3-(aminomethyl)benzyl)urea)
- Test material form:
- solid
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, domestic (adaptation not specified)
- Details on inoculum:
- Samples of secondary effluent were obtained as the test inoculum from a sewage plant treating predominantly domestic sewage (Nanjing Chengdong Sewage Treatment Plant) Aerobic conditions were maintained in the effluent by aeration from a laboratory supply of oil-free compressed air. (Batch No: 120120920) On the day of the test, the test inoculum was prepared by filtering the sample of sewage effluent through a coarse rilter. (discarding the first 200 mL) and collecting the remaining filtrates. This inoculum was maintained under aerobic conditions in the test area until use.
- Duration of test (contact time):
- ca. 28 d
Initial test substance concentration
- Initial conc.:
- ca. 60 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
Results and discussion
% Degradation
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- ca. 1.41
- Sampling time:
- 28 d
- Details on results:
- During the test, the temperature was kept between 19.6°C to 21.9°C. The test is valid because the biodegradation of the reference substance achieved 71.9% within 14 days, which was great than 60%, and biodegradation of the toxicity control was 26.7% within 14 days, which was great than 25%. The test substance did not inhibit the degradation of the reference substance and was therefore not toxic to the inoculum. Oxygen consumption in inoculum blanks was 1.21 mg O2/litre after 28-day test, which was less than 1.5 mg O2/L. Oxygen concentration in "test' was 7.41 mg O2/L after 28-day test, which was great than 0.5 mg O2/L. Therefore the test would be considered valid.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The result indicated the biodegradation rate of the test substance was 1.41% after 28 days, which indicated that Addukt TI80-MXDA is not readily biodegradable.
- Executive summary:
The study was conducted according to the guidelines of SEPA HJ/T 153, "the guidelinesfor the testing of chemicals"; and with the reference to Part C.4-E (Closed Bottle Test) of EC Methods for the Determination of Ecotoxicity; Annex to Council Regulation (EC), L142 (2008); OECD Procedure 301D; Closed Bottle test and US Environmental Protection Agency (EPA), Office of Prevention, Pesticides and Toxic Substances, (OPPTS) Method 835.3110 (o), adopted January 1998; GB/T 21831-2008, Chemicals-Ready biodegradability; Closed bottle test. Under valid conditions, the ready biodegradability of Addukt TI80-MXDA was determined in a 28-day dissolve oxygen depletion using secondary effluent from a domestic waste water treatment plant.
During the test, the temperature was kept at (20士2) °C. The test is valid because the level of biodegradation of the reference substance reached 71.9% within 14 days, which was great than 60%, and biodegradation of the toxicity control was 26.9% within 14 days, which was great than 25%. The test substance did not inhibit the degradation of the reference substance and was therefore not toxic to the inoculum. Oxygen consumption in inoculum blanks was 1.21 mg O2/litre after 28-day test, which was less than 1.5 mg O2/L.
Oxygen concentration in "test" was 7.41 mg O2/L after 28-day test, which was great than 0.5 mg O2/L. Thus the study met the acceptability criteria prescribed by the protocol and was considered valid.
Finally the results showed that under valid conditions, the biodegradation rate of Addukt TI80-MXDA was 1.41% biodegradation after 28-days.
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