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EC number: 209-052-0 | CAS number: 553-86-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to OECD guiline 111
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- Study performed under same rules as GLP
Test material
- Reference substance name:
- (3H)-benzofuran-2-one
- EC Number:
- 209-052-0
- EC Name:
- (3H)-benzofuran-2-one
- Cas Number:
- 553-86-6
- Molecular formula:
- C8H6O2
- IUPAC Name:
- 2,3-dihydro-1-benzofuran-2-one
- Details on test material:
- Purity >= 98%
Constituent 1
Study design
- Analytical monitoring:
- yes
- Buffers:
- Buffer solution pH4: 100mL of potassium hydrogenophtalate 0.1M + 0.8mL of NaOH 0.1N, ultrapur water is added to 200mL.
Buffer solution pH7: 100mL of potassium hydrogenophosphate 0.1M + 59.2mL of NaOH 0.1N, ultrapur water is added to 200mL.
Buffer solution pH9: 100mL of boric acid + 42.6mL of NaOH 0.1M, KCl 0.1M is added to 200mL.
- Buffers and water used
Potassium hydrogenophtalate MERCK, batch: 724009
NaOH 0.1N VWR, batch: 100210515
Potassium hydrogenophosphate VWR, batch: 0602286
Boric acid 99% ACROS, batch: A0243276
KCl pa ACROS, batch: A017996301
Ultrapur water
- Molarity and pH of buffer solutions (See above).
The pH of each buffer solution was measured after each preparation with pHmeter: Metrohm 736.
Buffer solution pH4: 4.0
Buffer solution pH7: 7.0
Buffer solution pH9: 9.0
Duration of testopen allclose all
- Duration:
- 503 h
- pH:
- 4
- Temp.:
- 10 °C
- Initial conc. measured:
- 1 165 - 1 244 mg/L
- Duration:
- 122 h
- pH:
- 4
- Temp.:
- 25 °C
- Initial conc. measured:
- 1 238 - 1 471 mg/L
- Duration:
- 31 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 1 118 - 1 154 mg/L
- Duration:
- 51 h
- pH:
- 7
- Temp.:
- 10 °C
- Initial conc. measured:
- 1 024 - 1 085 mg/L
- Duration:
- 27 h
- pH:
- 7
- Temp.:
- 25 °C
- Initial conc. measured:
- 1 032 - 1 442 mg/L
- Duration:
- 5 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 1 205 - 1 603 mg/L
- Duration:
- 3 h
- pH:
- 9
- Temp.:
- 10 °C
- Initial conc. measured:
- 1 415 - 1 687 mg/L
- Duration:
- 2 h
- pH:
- 9
- Temp.:
- 25 °C
- Initial conc. measured:
- 1 167 - 1 240 mg/L
- Duration:
- 1 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 961 - 1 128 mg/L
- Number of replicates:
- 2 replicates per buffer solution
Results and discussion
- Preliminary study:
- Study condition: at 50°C (in an oven) for 5 days
% Degradation
pH4 100
pH7 100
pH9 100
Conclusion:
More than 10% of hydrolysis is observed after 5 days for each pH, thus the test substance is considered hydrolytically unstable and additional testing is required. - Transformation products:
- yes
Identity of transformation products
- No.:
- #1
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- (2-hydroxyphenyl)acetic acid
- Inventory number:
- InventoryMultipleMappingImpl [inventoryEntryValue=EC 210-393-2]
- CAS number:
- 614-75-5
- Identity:
- Acetic acid, (o-hydroxyphenyl)-
- Identity:
- Benzeneacetic acid, 2-hydroxy-
- Molecular formula:
- C8H8O3
- Molecular weight:
- 152.147
- SMILES notation:
- OC(=O)Cc1ccccc1O
- InChl:
- InChI=1/C8H8O3/c9-7-4-2-1-3-6(7)5-8(10)11/h1-4,9H,5H2,(H,10,11)
- Details on hydrolysis and appearance of transformation product(s):
- Hydrolysis substance of 2-Coumaranone is o-hydroxyphenylacetic acid (CAS 614-75-5; EINECS 210-393-2) and is identified as AOHPA in this RSS
Total recovery of test substance (in %)open allclose all
- % Recovery:
- 94.4 - 101
- pH:
- 4
- Temp.:
- 10 °C
- Duration:
- 390 - 503 h
- % Recovery:
- 94.7 - 103.7
- pH:
- 4
- Temp.:
- 25 °C
- Duration:
- 97 - 122 h
- % Recovery:
- 95.1 - 103
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 24 - 31 h
- % Recovery:
- 92.2 - 100.7
- pH:
- 7
- Temp.:
- 10 °C
- Duration:
- 46 - 51.5 h
- % Recovery:
- 93.4 - 101
- pH:
- 7
- Temp.:
- 25 °C
- Duration:
- 26 - 28 h
- % Recovery:
- 75 - 100
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5.25 - 5.5 h
- % Recovery:
- 62 - 95
- pH:
- 9
- Temp.:
- 10 °C
- Duration:
- 2.25 - 3 h
- % Recovery:
- 70 - 97
- pH:
- 9
- Temp.:
- 25 °C
- Duration:
- 1.5 - 1.75
- % Recovery:
- 93.7 - 113
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 0.75 - 1 h
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 10 °C
- Hydrolysis rate constant:
- 0 min-1
- DT50:
- 158.6 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 4
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 min-1
- DT50:
- 41.1 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 4
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0.002 min-1
- DT50:
- 7.5 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 10 °C
- Hydrolysis rate constant:
- 0 min-1
- DT50:
- 40.3 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.001 min-1
- DT50:
- 9.2 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0.014 min-1
- DT50:
- 0.9 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 10 °C
- Hydrolysis rate constant:
- 0.015 min-1
- DT50:
- 0.8 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.061 min-1
- DT50:
- 0.2 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0.494 min-1
- DT50:
- 1.4 min
- Type:
- second order
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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