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EC number: 224-623-4 | CAS number: 4430-31-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The reliability score is based on the study is similar to current OECD guideline but not GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- no details on test material (purity not indicated), no details on test animals and environmental conditions, observation period unknown (only until day 5 included in report), no details on dermal exposure.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Octahydro-2H-1-benzopyran-2-one
- EC Number:
- 224-623-4
- EC Name:
- Octahydro-2H-1-benzopyran-2-one
- Cas Number:
- 4430-31-3
- Molecular formula:
- C9H14O2
- IUPAC Name:
- octahydro-2H-1-benzopyran-2-one
- Test material form:
- liquid
1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
No details.
ENVIRONMENTAL CONDITIONS
No details.
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- No details specified.
- Duration of exposure:
- No details.
- Doses:
- 1250, 2500 and 5000 mg/kg bw
- No. of animals per sex per dose:
- Total of 4 (sex not specified).
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 5 days
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 500 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 200 - 5 700
- Mortality:
- See "any other information results"
- Clinical signs:
- other: At 2500 mg/kg bw lethargy was observed in one animal on day 1. All other animals showed no abnormalities at any dose level.
- Gross pathology:
- See "any other information results"
- Other findings:
- Irritation: See "any other information results"
Any other information on results incl. tables
Deaths per day after exposure to Bicyclononalactone
Dose mg/kg bw |
Deaths/day |
total |
1250 |
0 |
0/4 |
2500 |
1/1 |
1/4 |
5000 |
2/1, 1/2 |
3/4 |
Skin irritation after exposure to Bicyclononalactone
Dose mg/kg bw | 1250 | 2500 | 5000 |
Redness: | |||
Slight | 1/3 * | 1/2 ** | |
Moderate | 4/4 | 2/3 | 1/2 |
Edema: | |||
Slight | 4/4 | 3/3 | 2/2 |
* 1 animal dead prior to reading
** 2 animals dead prior to reading
Necropsy observations after exposure to Bicyclononalactone
No. of rats |
||||
Doses mg/kg bw |
1250 |
2500 |
5000 |
|
Normal |
|
2 |
1 |
|
Exudate, nose/mouth, yellow |
|
|
1 |
|
Exudate, anogenital, brown |
|
1 |
2 |
|
Intestines, areas red | 1 | 3 | ||
Intestines, areas yellow | 1 | |||
Intestines, bloated | 3 | 1 | 3 | |
Stomach, areas red | 1 | |||
Liver dark | 3 | 1 | ||
Liver mottled | 1 | 3 | ||
Lungs dark | 2 | |||
Lungs areas dark | 1 | 1 | ||
Kidney dark | 1 | 1 | ||
Kidney mottled | 2 | |||
Skin edema | 2 | |||
Skin redness | 2 | |||
Intestines, contained green fluid | 1 | |||
Liver white nodules | 1 | |||
Gall bladder large | 1 | |||
Kidney pale | 1 |
Applicant's summary and conclusion
- Interpretation of results:
- other: Not acute harmful.
- Remarks:
- According to Regulation (EC) No. 1272/2008 and its amendments.
- Conclusions:
- An LD50 of 3500 mg/kg bw was obtained in the acute dermal toxicity study with rabbits. According to GHS the substance needs to be classified for acute dermal toxicity category 5 and labelled with H313: May be harmful in contact with skin.
- Executive summary:
In an acute dermal toxicity study 3 groups of 4 rabbits were dermally exposed to 1250, 2500 and 5000 mg/kg bw of Bicyclononalactone. The rabbits were observed for signs of toxicity and pharmacological effects for a period of 5 days. Deaths occurred on day 1 and 2. At 2500 mg/kg bw lethargy was observed in one animal on day 1 and one animal died. At 5000 mg/kg bw 3/4 animals died by day 2. Slight to moderate redness and slight edema was observed in all animals. Based on the results, an LD50 of 3500 mg/kg bw was obtained in the acute dermal toxicity study with rabbits.
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