Registration Dossier
Registration Dossier
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EC number: 246-874-9 | CAS number: 25340-17-4
Endpoint summary
Administrative data
Description of key information
Acute oral, dermal and inhalation toxicity studies using mixed DEB.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- > 2 100 ppm air
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 2 000 mg/kg bw
Additional information
The acute oral LD50 of DEB mixed isomers in rats is >2000 mg/kg bw (from 2050 to 6900 mg/kg bw). Signs of toxicity include hypoactivity, red nasal discharge, urinary staining, partially closed eyes, prostration and decreased food consumption, ataxia, tremors, clear nasal and oral discharge, wet rales, soft stool, fecal staining, abdominal griping, blue pigmentation and hypothermia. Necropsy of decedents showed blue pigmentation of all/most soft tissues and/or blue fluid in the gastrointestinal tract and urinary bladder, irritation or corrosive effects in the stomach, intestine and urinary bladder.
For acute dermal toxicity (24-hour) the LD50 is >2000 mg/kg bw. Skin irritation consisting of red, swollen and scabbed skin was noted. There were no deaths in any of the acute dermal toxicity studies.
From a study with only limited information available, the LC50 for inhalation toxicity (7-hr) in rats is >2100 ppm ( 11520 mg/m3 highest technically feasible dose with a water bath at 100 degrees C). Clinical signs consisted of drowsiness observed at the end of exposure.
Justification for classification or non-classification
Due to the high LD and LC50 values for mixed DEB, there is no requirement for classification as acutely toxic.
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