Registration Dossier
Registration Dossier
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EC number: 204-671-2 | CAS number: 124-02-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Diallylamine [124-02-7]: Review of Toxicological Literature
- Author:
- US National Toxicology Program
- Year:
- 1 997
- Bibliographic source:
- US National Toxicology Program
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- other: dermal toxicity
- Limit test:
- no
Test material
- Reference substance name:
- Diallylamine
- EC Number:
- 204-671-2
- EC Name:
- Diallylamine
- Cas Number:
- 124-02-7
- Molecular formula:
- C6H11N
- IUPAC Name:
- diallylamine
Constituent 1
- Specific details on test material used for the study:
- Purity not provided.
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- (albino)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Rabbits age not specified.
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Applied to clipped intact abdominal skin
- Duration of exposure:
- 24 hours
- Doses:
- 215, 464, 1000 and 2150 mg/kg (2.21, 4.78, 10.29 and 22.13 mmol/kg)
- No. of animals per sex per dose:
- 2 males and 2 females per dose.
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 562 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 383 - <= 825
- Mortality:
- All deaths occured within 24 hours of dosing, most in less than 4 hours
numbers of deaths per dose
215 MG/KG (0/4),
464 MG/KG (1/4),
1000 MG/KG (4/4),
2150 MG/KG (4/4). - Clinical signs:
- Necrosis, erythema and edema were observed.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The LD50 in rabbits was reported as 562 mg/kg.
- Executive summary:
Diallylamine was applied for 24 hours to the intact skin of New Zealand white rabbits, at doses of 215, 464, 1000 and 2150 mg/kg (2.21, 4.78, 10.29 and 22.13 mmol/kg). Necrosis, erythema and edema were observed. All deaths occured within 24 hours of dosing, most in less than 4 hours.
The LD50 was reported as 562 mg/kg.,
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