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Diss Factsheets
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EC number: 203-536-5 | CAS number: 107-95-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
-Repeated dose toxicity: oral (GLP, OECD TG 407), NOAEL=1000 mg/kg bw/day
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Additional information
A 28-day repeated dose oral toxicity study of beta-alanine was conducted using male and female Crj:CD(SD)IGS rats according to OECD TG 407 under GLP conditions. 40, 200, and 1000 mg/kg (6 rats/sex/group) of beta-alanine, dissolved in water for injection, were administered by gavage 7 days a week for 28 days, followed by 14-day recovery period. During the dosing and recovery periods, no deaths occurred, and no treatment-related changes were observed in clinical signs, neurotoxicological observation, functional tests, body weights, food consumption, ophthalmoscopy, urinalysis, hematology, blood biochemistry, and organ weights. At the end of the recovery period, a yellow-white mass (20 × 20 × 10 mm) was found in the subcutis of the left inguinal region in one female of the 1000 mg/kg bw group. Histopathologically, this mass was recognized as adenocarcinoma in the mammary gland, and was considered spontaneous. In summary, no effects of beta-alanine on male and female SD rats receiving the maximum dose of 1000 mg/kg were observed. The NOEL and NOAEL of this study are considered to be 1000 mg/kg bw/day in both male and female rats.
Justification for classification or non-classification
On the basis of the study results, beta-alanine is not to be classified according to DSD and CLP classification criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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