Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 945-746-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The registered substance is hydrolytically stable at pH>5 and is not readily biodegradable. In addition, the biodegradation result obtained after 60 days does not allow us to conclude that the registered substance is not persistent in the environment even if, after a long period of time, the substance would be expected to ultimately biodegrade.
Based on a QSAR approach, the estimated BCF values of the registered substance well all comprised between 407 and 4219 L/kg, calculated using the experimental log Kow value at 5.05. Based on these available data, the registered substance seems to be bioaccumulable (log Kow > 4.5 and BCF > 2000 L/kg) but not very bioaccumulable (BCF < 5000 L/kg) according to PBT criteria. However, as the log Kow of the substance is high it may be expected to be found mostly in the adsorbed form and therefore more likely to be ingested than absorbed through the gills. At pHs found in the stomach of fish (generally comprised between 2 and 4), hydrolysis of the registered substance is expected to occur before biotransformation in the liver. In acidic conditions and up to pH 5, the registered substance is known to be unstable and will hydrolyze to give a poly-hydroxylated degradation product. The BCF value of this hydrolysis product / metabolite at acid pH (the diol form) is calculated to be low, at 12.9 L/kg. Therefore, we can conclude that the registered substance is not bioaccumulable.
Finally, the adsorption coefficient of the registered substance has been evaluated to be in the range of 150 to 3940, corresponding to a log Koc comprised between 2.18 and 3.60. This result indicates that the registered substance has a medium to slightly mobility in soils (according to P.J. McCall et al., 1981).
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.