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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
A preliminary hydrolysis test was conducted. At 23 °C, six different test media were studied. Based on the results, a hydrolysis half-life of approximately 4.5 seconds at 23 °C can be derived. Hydrolysis was found too rapid for performing a main study according to OECD TG 111.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 0.075 min
- at the temperature of:
- 23 °C
Additional information
A preliminary hydrolysis test was conducted in order to determine the need for a main hydrolysis test and suitable experimental conditions for this main test. At 23 °C, six different test media were studied: buffer solutions at pH 4, 7 and 9; pure HPLC water; and acetonitrile / HPLC water mixtures at v/v ratios of 30 : 70 and 10 : 90. Pure acetonitrile served as reference where no hydrolysis occurred.
After less than 1:30 minutes (sample preparation, including chromatographic separation), only for the first injections of the sample in acetonitrile : HPLC water (90 : 10, v/v) a test item signal could be detected. The intensity of this signals corresponds to approx. 2.7% of the reference signal in pure acetonitrile, decreased dramatically for the second injection and no signal could be observed for the third injection (injection run time 2 minutes). Reference samples in acetonitrile indicate no fade of the test item signal. Therefore, the hydrolytic half-life of the test item was reported to be significantly below 1 minute at 23 °C. The same can be assumed for the environmental typical temperature range. Due to this fast transformation, no hydrolysis testing on basis of the OECD 111 guideline could be performed.
Based on the results for acetonitrile : HPLC water (90 : 10, v/v), a hydrolysis half-life of approximately 4.5 seconds at 23 °C can be derived.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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