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Diss Factsheets
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EC number: 203-870-1 | CAS number: 111-44-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to fish, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 204 (Fish, Prolonged Toxicity Test: 14-day Study)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- No details provided
- Analytical monitoring:
- yes
- Details on sampling:
- Frequency of analysis: 0th, 7th, 14th day
- Vehicle:
- not specified
- Details on test solutions:
- No data
- Test organisms (species):
- Oryzias latipes
- Details on test organisms:
- No data
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 14 d
- Post exposure observation period:
- No data
- Hardness:
- Not specified
- Test temperature:
- 24 +/- 1°C
- pH:
- Not specified
- Dissolved oxygen:
- Not specified
- Salinity:
- Not specified
- Conductivity:
- Not specified
- Nominal and measured concentrations:
- Nominal concentrations: 100, 50.0, 25.0, 12.5, 6.25 mg/L (geometric ratio: 2.0), control
- Details on test conditions:
- TEST SYSTEM
- Fill volume: 1.8 L
- Aeration: no
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
TEST MEDIUM / WATER PARAMETERS: no data
OTHER TEST CONDITIONS
- Photoperiod: 16 hours light / 8 hours dark
EFFECT PARAMETERS MEASURED: Mortality
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 2
RANGE-FINDING STUDY: not specified - Reference substance (positive control):
- not specified
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 25 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- - Threshold level of lethal effect (14 d): 50.0 mg/L,
- Threshold level of observed effects (14 d): 50.0 mg/L,
- 50 % Lethal concentration (LC50) (7 d): > 100 mg/L, - Validity criteria fulfilled:
- not specified
- Conclusions:
- Following a 14-d exposure period, the LC50 of Bis(2-chloroethyl) ether to Oryzias latipes was found to be > 100 mg/L. Based on mortality or other observed effects (not specified), the NOEC was 25 mg/L.
- Executive summary:
This study was conducted on behalf of the Japanese Ministry of Environment (MOE). The methodology was based on OECD Technical Guideline N°204 under GLP. Nominal concentrations were 100, 50.0, 25.0, 12.5, 6.25 mg/L (geometric ratio: 2.0). One replicate was used per concentration with 10 fishes per test vessel. Following a 14-d exposure period, the LC50 of Bis(2-chloroethyl) ether to Oryzias latipes was found to be > 100 mg/L. Based on mortality or other observed effects (not specified), the NOEC was 25 mg/L. As no detailed information was available, a reliability factor of 2 was assigned to this guideline study.
Reference
Description of key information
The study selected as key information was conducted on behalf of the Japanese Ministry of Environment (MOE). The methodology was based on OECD Technical Guideline N°204 under GLP. Nominal concentrations were 100, 50.0, 25.0, 12.5, 6.25 mg/L (geometric ratio: 2.0). One replicate was used per concentration with 10 fishes per test vessel. Following a 14-d exposure period, the LC50 of Bis(2-chloroethyl) ether to Oryzias latipes was found to be > 100 mg/L. Based on mortality or other observed effects (not specified), the NOEC was 25 mg/L. As no detailed information was available, a reliability factor of 2 was assigned to this guideline study. Based on this result GHS-UN classification criteria are not met.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 25 mg/L
Additional information
Two bibliographic sources reported long-term toxicity data to fish.
The study selected as key information was conducted on behalf of the Japanese Ministry of Environment (MOE). The methodology was based on OECD Technical Guideline N°204 under GLP. While this guideline is no longer recommended to assess the long-term toxicity of chemicals to fish, this study was conducted before 2003 and is considered sufficienctly reliable for this assessment. Nominal concentrations were 100, 50.0, 25.0, 12.5, 6.25 mg/L (geometric ratio: 2.0). One replicate was used per concentration with 10 fishes per test vessel. Following a 14-d exposure period, the LC50 of Bis(2-chloroethyl) ether to Oryzias latipes was found to be > 100 mg/L. Based on mortality or other observed effects (not specified), the NOEC was 25 mg/L. As no detailed information was available, a reliability factor of 2 was assigned to this guideline study.
The only other available data on the long-term toxicity of Bis(2-chlorethyl) ether is provided within a report on chloroalkyl ethers published by the Office of Water Planning and Standards from the U.S. Environmental Protection Agency. Based on an embryo-larval test conducted on the fathead minnow (Pimephales promelas), the NOAEC of Bis(2-chloroethyl) ether was determined to be 19 mg/L. While U.S. EPA reports are subjected to a formal review, the minimal information provided in this report does not allow to fully judge the reliability of this data. Accordingly, this published NOAEC for the chemical safety assessment of Bis(2-chloroethyl) ether.
Conclusion: Based on available information the substance is not considered to exhibit significant long-term toxicity to fish.
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