Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-656-8 | CAS number: 109-21-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Aliphatic alcohols and alkyl esters: Narcotic and lethal potencies to tadpoles and to rabbits.
- Author:
- Munch
- Year:
- 1 972
- Bibliographic source:
- Industrial Medicine and Surgery, 41(4), 31-33
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- In the current study the narcotic potencies and lethal effetcs of aliphatic alcohols and their alkyl esters were assessed. A group of 10 - 35 male and female rabbits was treated with the test item. Administration of the test material was by stomach tube. The lethal dose (LD50) which was the quantity that caused death in 50% of the treated rabbits was also determined.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Butyl butyrate
- EC Number:
- 203-656-8
- EC Name:
- Butyl butyrate
- Cas Number:
- 109-21-7
- Molecular formula:
- C8H16O2
- IUPAC Name:
- butyl butanoate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 1.5 - 2.5 kg
- Fasting period before study: no
- Acclimation period: 2 weeks
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- Not specified.
- No. of animals per sex per dose:
- 10 - 35 animals in total
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 9 518 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
Based on the molecular weight of 144.21 g/mol and an LD50 value of 66 mmol/kg, an LD value of 9518 mg/kg was calculated.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 was determined to be 9518 mg/kg.
- Executive summary:
In the current study the narcotic potencies and lethal effects of aliphatic alcohols and their alkyl esters were assessed. A group of 10 - 35 male and female rabbits was treated with the test item. Administration of the test material was by stomach tube.
The lethal dose (LD50) which was the quantity that caused death in 50% of the treated rabbits was also determined.
The LD50 was determined to be 9518 mg/kg. No other details or results were provided. However, according to the CLP Regulation the test item should not be classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
