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Diss Factsheets
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EC number: 944-482-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 15, 1998 - December 29, 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- (1987)
- Deviations:
- yes
- Remarks:
- Limited details on test material, no purity, no details on environmental conditions.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction mass of 1-(3,3-dimethylcyclohex-1-en-1-yl)pent-4-en-1-one and 1-(5,5-dimethylcyclohex-1-en-1-yl)pent-4-en-1-one
- EC Number:
- 944-482-9
- Molecular formula:
- C13H20O
- IUPAC Name:
- Reaction mass of 1-(3,3-dimethylcyclohex-1-en-1-yl)pent-4-en-1-one and 1-(5,5-dimethylcyclohex-1-en-1-yl)pent-4-en-1-one
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Sprague Dawley derived
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ace Animals, Inc., Boyertown, PA, USDA License #23-B-009
- Age at study initiation: No data
- Weight at study initiation: males: 238 - 253g; females: 209 - 241g
- Fasting period before study: fasted overnight for approx. 18-24 hours prior to dosing
- Housing: Animals were either single or double housed in suspended stainless steel wire-mesh cages
- Diet: Free access to Agway Prolab 3000
- Water: Free access to city water
- Acclimation period: at least 7 days
ENVIRONMENTAL CONDITIONS set to maintain
- Temperature (°C): targeted 21
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Individual doses, calculated on the basis of bodyweight and test material density (0.93 g/mL), were administered by syringe and suitable intubation tube.
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Body weight: just prior to administration and weekly thereafter
Toxicity and mortality: twice daily seven days a week after administration
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One male was found dead on day 7.
- Clinical signs:
- On day 1 in the morning, all animals had decreased locomotion. One female and two males appeared dehydrated therefore all animals were given a water bottle. On day 1, in the afternoon, one female had decreased locomotion, all other animals appeared normal.
- Body weight:
- All surviving animals showed normal bodyweight increases on the 14th day of the observation period.
- Gross pathology:
- There were no gross abnormalities in any of the surviving animals. One male was found to have both kidneys dilated, the liver was pale pink, stomach and intestines were distended with gas.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Remarks:
- According to Regulation (EC) No. 1272/2008.
- Conclusions:
- The acute oral toxicity test with the substance showed an LD50 of >2000 mg/kg bw.
- Executive summary:
In this study performed according to OECD TG 401 guideline and GLP principles, 10 rats (5 males and 5 females) were administered with the substance at a dose level of 2000 mg/kg bw. One male was found dead on day 7. On day 1 in the morning, all animals had decreased locomotion. One female and two males appeared dehydrated therefore all animals were given a water bottle. On day 1, in the afternoon, one female had decreased locomotion, all other animals appeared normal. There were no gross abnormalities in any of the surviving animals. One male was found to have both kidneys dilated, the liver was pale pink, stomach and intestines were distended with gas. Based on the results in this study, the acute oral LD50 for the substance in male and female rats was determined to be >2000 mg/kg bw and the substance does not have to be classified for acute toxicity by the oral route according to Regulation (EC) No. 1272/2008.
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