Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-860-2 | CAS number: 2920-38-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Dec 1998 to Jun 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- p-phenylbenzonitrile
- EC Number:
- 220-860-2
- EC Name:
- p-phenylbenzonitrile
- Cas Number:
- 2920-38-9
- Molecular formula:
- C13H9N
- IUPAC Name:
- [1,1'-biphenyl]-4-carbonitrile
- Reference substance name:
- p-phenylbenzaldehyde
- EC Number:
- 221-742-3
- EC Name:
- p-phenylbenzaldehyde
- Cas Number:
- 3218-36-8
- Molecular formula:
- C13H10O
- IUPAC Name:
- biphenyl-4-carbaldehyde
- Reference substance name:
- unknown
- IUPAC Name:
- unknown
- Test material form:
- solid: bulk
Constituent 1
impurity 1
impurity 2
- Specific details on test material used for the study:
- Batch FH III/TVT 281098
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- age 8 weeks male/12 weeks female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 200mg/kg: 2000mg/kg
- No. of animals per sex per dose:
- 3 per dose per sex
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50 cut-off
- Effect level:
- ca. 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- other: piloerection in all animals sedation in the high dosed males and 2/3 females abnormal posture in a singel case huchered posture in all high dosed animals closed eyes ni all high dosed males and chromodaccryorrhoie in 1/3 high dosed females.
- Gross pathology:
- all animals were normal at the post mortem examination
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- 4-Phenylbenzonitrile does not have to be classified as harmfull according to GHS
- Executive summary:
4-Phenylbenzonitrile does not have to be classified as harmfull according to GHS
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
